ArticleNature communications2021
Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 1 citations in OpenAlex.
- Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong.bioRxiv : the preprint server for biology · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.Science advances · 2026Article
- A species rules syntax model accurately organizes birdsong syllables into songs.Scientific reports · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.bioRxiv : the preprint server for biology · 2026Article
- Article
- Genomic Investigations of Spoken and Written Language Abilities: A Guide to Advances in Approaches, Technologies, and Discovery.Journal of speech, language, and hearing research : JSLHR · 2025Review
- The songbird basal ganglia connectome.bioRxiv : the preprint server for biology · 2025Article
- Change of Spiny Neuron Structure in the Basal Ganglia Song Circuit and Its Regulation by miR-9 during Song Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review.PeerJ · 2025Review
- An affordable solution for investigating zebra finch intracranial electroencephalography (iEEG) signals.PloS one · 2025Article
- Neurochemical Characterization of Dopaminoceptive Cells in Song Control Nuclei of Canaries and Their Activation During Song Production: A Multiplex Fluorescent In Situ Hybridization Study.The Journal of comparative neurology · 2024Article
- Article
- Single-cell transcriptomics reveals the brain evolution of web-building spiders.Nature ecology & evolution · 2023Article
- Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling.Cell discovery · 2023Article
- Analogies of human speech and bird song: From vocal learning behavior to its neural basis.Frontiers in psychology · 2023Review
- Striatal Injury Induces Overall Brain Alteration at the Pallial, Thalamic, and Cerebellar Levels.Biology · 2022Article
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits.Science (New York, N.Y.) · 2021Article
- What Is the Role of Thalamostriatal Circuits in Learning Vocal Sequences?Frontiers in neural circuits · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Disruption of the transcription factor FoxP2, which is enriched in the basal ganglia, impairs vocal development in humans and songbirds. The basal ganglia are important for the selection and sequencing of motor actions, but the circuit mechanisms governing accurate sequencing of learned vocalizations are unknown. Here, we show that expression of FoxP2 in the basal ganglia is vital for the fluent initiation and termination of birdsong, as well as the maintenance of song syllable sequencing in adulthood. Knockdown of FoxP2 imbalances dopamine receptor expression across striatal direct-like and indirect-like pathways, suggesting a role of dopaminergic signaling in regulating vocal motor sequencing. Confirming this prediction, we show that phasic dopamine activation, and not inhibition, during singing drives repetition of song syllables, thus also impairing fluent initiation and termination of birdsong. These findings demonstrate discrete circuit origins for the dysfluent repetition of vocal elements in songbirds, with implications for speech disorders.
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