Evidence map›Paper›PMID 33976157›Full record

ArticleNature communications2021

Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.

Mariana Borsa, Niculò Barandun, Fabienne Gräbnitz, Isabel Barnstorf, Nicolas S Baumann, Katharina Pallmer, Samira Baumann, Dominique Stark, Miroslav Balaz, Nathalie Oetiker and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

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  4. CD8Science China. Life sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Mariana BorsaInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.ORCID 0000-0003-1519-2597
Niculò Barandun *Institute of Microbiology, ETH Zürich, Zurich, Switzerland.
Fabienne Gräbnitz *Institute of Microbiology, ETH Zürich, Zurich, Switzerland.
Isabel BarnstorfInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.
Nicolas S BaumannInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.
Katharina PallmerInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.
Samira BaumannInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.ORCID 0000-0003-0077-4228
Dominique StarkInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.ORCID 0000-0002-3214-7950
Miroslav BalazInstitute of Food Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland.
Nathalie OetikerInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.
Franziska WagenInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.
Christian WolfrumInstitute of Food Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland.ORCID 0000-0002-3862-6805
Anna Katharina SimonMedical Sciences Division, NDORMS, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Nicole JollerInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-1996-1672
Yves BarralInstitute of Biochemistry, ETH Zürich, Zurich, Switzerland.ORCID 0000-0002-0989-3373
Roman SpörriInstitute of Microbiology, ETH Zürich, Zurich, Switzerland.ORCID 0000-0001-9277-6997
Annette OxeniusInstitute of Microbiology, ETH Zürich, Zurich, Switzerland. oxenius@microbio.ethz.ch.ORCID 0000-0002-2079-2354
ETH Zurich · CHUniversity of Oxford · GBUniversity of Zurich · CH

Funding

Wellcome TrustWellcome Trust 103830/Z/14/Z
6 · The paper itself

Abstract

Efficient immune responses rely on heterogeneity, which in CD8

Indexed as

AgingAnimalsAsymmetric Cell DivisionCD8-Positive T-LymphocytesCell ProliferationGene Expression RegulationImmunity, InnateImmunologic MemoryInterferon-gammaInterleukin-1betaInterleukin-2 Receptor beta SubunitLectins, C-TypeLymphocyte ActivationMiceNK Cell Lectin-Like Receptor Subfamily KReceptors, CXCR3Cxcr3 protein, mouseIL1B protein, mouseIl2rb protein, mouseInterferon-gammaInterleukin-1betaInterleukin-2 Receptor beta SubunitKlrg1 protein, mouseKlrk1 protein, mouseLectins, C-TypemTOR protein, mouseNK Cell Lectin-Like Receptor Subfamily KReceptors, CXCR3Receptors, ImmunologicReceptors, Interleukin-7SirolimusTOR Serine-Threonine Kinases

Identifiers

PMID33976157
PMCPMC8113513
OpenAlexW3163538648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.