ArticleNature communications2021
A cortico-collicular pathway for motor planning in a memory-dependent perceptual decision task.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Anatomy of Cerebro-cerebellar Circuits in Motor Control.Cerebellum (London, England) · 2026Review
- Somatosensory cortex shapes perceptual decision bias via the superior colliculus.Research square · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- Stimulus selection enhances value-modulated somatosensory processing in the superior colliculus.PLoS biology · 2025Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Article
- Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Differential Formation of Motor Cortical Dynamics during Movement Preparation According to the Predictability of Go Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Superior colliculus bidirectionally modulates choice activity in frontal cortex.Nature communications · 2023Article
- Functional alterations of the prefrontal circuit underlying cognitive aging in mice.Nature communications · 2023Article
- Collicular circuits supporting the perceptual, motor and cognitive demands of ethological environments.Current opinion in neurobiology · 2023Review
- The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.Neuroscience bulletin · 2023Article
- M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals.PLoS biology · 2023Article
- Superior colliculus cell types bidirectionally modulate choice activity in frontal cortex.bioRxiv : the preprint server for biology · 2023Article
- Influence of Recent Trial History on Interval Timing.Neuroscience bulletin · 2023Article
- Article
- Where Actions Meet Outcomes: Medial Prefrontal Cortex, Central Thalamus, and the Basal Ganglia.Frontiers in behavioral neuroscience · 2022Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Survival in a dynamic environment requires animals to plan future actions based on past sensory evidence, known as motor planning. However, the neuronal circuits underlying this crucial brain function remain elusive. Here, we employ projection-specific imaging and perturbation methods to investigate the direct pathway linking two key nodes in the motor planning network, the secondary motor cortex (M2) and the midbrain superior colliculus (SC), in mice performing a memory-dependent perceptual decision task. We find dynamic coding of choice information in SC-projecting M2 neurons during motor planning and execution, and disruption of this information by inhibiting M2 terminals in SC selectively impaired decision maintenance. Furthermore, we show that while both excitatory and inhibitory SC neurons receive synaptic inputs from M2, these SC subpopulations display differential temporal patterns in choice coding during behavior. Our results reveal the dynamic recruitment of the premotor-collicular pathway as a circuit mechanism for motor planning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.