Evidence map›Paper›PMID 33975973›Full record

ArticlemSystems2021

Mycobacteria Tolerate Carbon Monoxide by Remodeling Their Respiratory Chain.

Katherine Bayly, Paul R F Cordero, Ashleigh Kropp, Cheng Huang, Ralf B Schittenhelm, Rhys Grinter, Chris Greening

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Carbon Monoxide and Prokaryotic Energy Metabolism.International journal of molecular sciences · 2025
    Review
  5. Antibiotics (Basel, Switzerland) · 2024
    Review
  6. Membrane-Bound Redox Enzyme CytochromeInternational journal of molecular sciences · 2024
    Article
  7. Review
  8. Improving carbon monoxide tolerance ofFrontiers in bioengineering and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Katherine Bayly *Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Paul R F Cordero *Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Ashleigh KroppDepartment of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Cheng HuangMonash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Ralf B SchittenhelmMonash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Rhys GrinterDepartment of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia rhys.grinter@monash.edu chris.greening@monash.edu.ORCID https://orcid.org/0000-0002-8195-5348
Chris GreeningDepartment of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia rhys.grinter@monash.edu chris.greening@monash.edu.ORCID https://orcid.org/0000-0001-7616-0594
Australian Regenerative Medicine Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon monoxide (CO) gas is infamous for its acute toxicity. This toxicity predominantly stems from its tendency to form carbonyl complexes with transition metals, thus inhibiting the heme-prosthetic groups of proteins, including respiratory terminal oxidases. While CO has been proposed as an antibacterial agent, the evidence supporting its toxicity toward bacteria is equivocal, and its cellular targets remain poorly defined. In this work, we investigate the physiological response of mycobacteria to CO. We show that

Indexed as

carbon monoxideMycobacteriumproteomicsrespiratory oxidases

Identifiers

PMID33975973
PMCPMC8125079
OpenAlexW3161583162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.