Evidence map›Paper›PMID 33975957›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

PIEZO ion channel is required for root mechanotransduction in

Seyed A R Mousavi, Adrienne E Dubin, Wei-Zheng Zeng, Adam M Coombs, Khai Do, Darian A Ghadiri, William T Keenan, Chennan Ge, Yunde Zhao, Ardem Patapoutian

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 109 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Piezo3 is a novel mechanosensitive Piezo ion channel in vertebrates.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Open biology · 2025
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  14. Article
  15. Article
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  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Seyed A R MousaviDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037; smousavi@scripps.edu ardem@scripps.edu.
Adrienne E DubinDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0003-4683-7175
Wei-Zheng ZengDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0002-1480-032X
Adam M CoombsDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037.
Khai DoDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037.
Darian A GhadiriDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037.
William T KeenanDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037.
Chennan GeSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92037.ORCID 0000-0002-5435-9639
Yunde ZhaoSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92037.ORCID 0000-0002-7224-8449
Ardem PatapoutianDepartment of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037; smousavi@scripps.edu ardem@scripps.edu.ORCID 0000-0003-0726-7034
Scripps Research Institute · USUniversity of California San Diego · US

Funding

Molecular understanding of membrane sensorsR01HL143297 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI PATAPOUTIAN, ARDEM, WARD, ANDREW BARRETT · 2019 to 2022
$3.2M
Molecular mechanisms of auxin-mediated plant developmentR01GM114660 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHAO, YUNDE · 2015 to 2018
$1.2M
NHLBI NIH HHS R01 HL143297NIGMS NIH HHS R01 GM114660
6 · The paper itself

Abstract

Plant roots adapt to the mechanical constraints of the soil to grow and absorb water and nutrients. As in animal species, mechanosensitive ion channels in plants are proposed to transduce external mechanical forces into biological signals. However, the identity of these plant root ion channels remains unknown. Here, we show that

Indexed as

ArabidopsisArabidopsis ProteinsMechanotransduction, CellularMembrane Transport ProteinsPlant RootsArabidopsis ProteinsAT2G48060 protein, ArabidopsisMembrane Transport ProteinsArabidopsision channelsmechanosensationPIEZOroot

Identifiers

PMID33975957
PMCPMC8158017
OpenAlexW3163172095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.