Evidence map›Paper›PMID 33975953›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in

Fangfang Zhang, Xuechen Zhu, Pan Wang, Qing He, Huimei Huang, Tianrui Zheng, Yongyu Li, Hong Jia, Linping Xu, Huaxiang Zhao and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Fangfang ZhangInstitute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, 710061 Xi'an, China.
Xuechen ZhuKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 310024 Hangzhou, China.
Pan WangTsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Qing HeInstitute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, 710061 Xi'an, China.
Huimei HuangDepartment of Nephrology, Xi'an Children's Hospital, The Affiliated Children's Hospital of Xi'an Jiaotong University, 710061 Xi'an, China.
Tianrui ZhengMinistry of Education (MOE) Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Yongyu LiMinistry of Education (MOE) Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Hong JiaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, 710061 Xi'an, China.
Linping XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, 710061 Xi'an, China.
Huaxiang ZhaoDepartment of Orthodontics, College of Stomatology, Xi'an Jiaotong University, 710061 Xi'an, China.
Gabriele ColozzaDepartment of Biological Chemistry, University of California, Los Angeles, CA 90095-1662.ORCID 0000-0003-4517-3389
Qinghua TaoBeijing Advanced Innovation Center for Structural Biology, 100084 Beijing, China; qhtaolab@mail.tsinghua.edu.cn ederobertis@mednet.ucla.edu dingyi1510@xjtu.edu.cn.ORCID 0000-0002-2929-1919
Edward M De RobertisDepartment of Biological Chemistry, University of California, Los Angeles, CA 90095-1662 qhtaolab@mail.tsinghua.edu.cn ederobertis@mednet.ucla.edu dingyi1510@xjtu.edu.cn.ORCID 0000-0002-7843-1869
Yi DingInstitute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, 710061 Xi'an, China; qhtaolab@mail.tsinghua.edu.cn ederobertis@mednet.ucla.edu dingyi1510@xjtu.edu.cn.ORCID 0000-0001-7525-7124
Xi'an Jiaotong University · CNTsinghua University · CNUniversity of California, Los Angeles · USBeijing Advanced Sciences and Innovation Center · CNPeking University · CNWestlake University · CNXi’an Children’s Hospital · CN

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA016042
6 · The paper itself

Abstract

Fibroblast growth factor (FGF)/extracellular signal-regulated kinase (ERK) signaling plays a crucial role in anterior-posterior (A-P) axial patterning of vertebrate embryos by promoting posterior development. In our screens for novel developmental regulators in

Indexed as

AnimalsCytokinesEmbryonic DevelopmentExtracellular Signal-Regulated MAP KinasesHEK293 CellsHumansReceptors, Fibroblast Growth FactorXenopus laevisXenopus ProteinsCytokinesExtracellular Signal-Regulated MAP KinasesReceptors, Fibroblast Growth FactorXenopus Proteinsanterior–posterior patterningembryonic developmentFAM3B cytokineFGF signalingXenopus laevis

Identifiers

PMID33975953
PMCPMC8158011
OpenAlexW3162629388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.