Evidence map›Paper›PMID 33975935›Full record

ArticlemBio2021

Endothelial Exosome Plays a Functional Role during Rickettsial Infection.

Yakun Liu, Changcheng Zhou, Zhengchen Su, Qing Chang, Yuan Qiu, Jiani Bei, Angelo Gaitas, Jie Xiao, Alexandra Drelich, Kamil Khanipov and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Infection and immunity · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Cells · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Yakun Liu *Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Changcheng Zhou *Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Zhengchen Su *Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Qing ChangDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Yuan QiuDepartment of Mathematics and Statistics, Texas Tech University, Lubbock, Texas, USA.
Jiani BeiDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Angelo GaitasThe Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jie XiaoDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Alexandra DrelichDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Kamil KhanipovDepartment of Pharmacology, University of Texas Medical Branch, Galveston, Texas, USA.
Yang JinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University Medical Campus, Boston, Massachusetts, USA.
Georgiy GolovkoDepartment of Pharmacology, University of Texas Medical Branch, Galveston, Texas, USA.
Tais B SaitoDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA tais.berellisaito@nih.gov bigong@utmb.edu.
Bin GongDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA tais.berellisaito@nih.gov bigong@utmb.edu.ORCID 0000-0002-3929-3897
The University of Texas Medical Branch at Galveston · USBoston University · USIcahn School of Medicine at Mount Sinai · USTexas Tech University · US

Funding

Epac1 Plays a Critical Role in Bacterial Adhesion during RickettsiosesR01AI121012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2016 to 2020
$1.9M
Mechanistic insights of inflammation and organ failure after trauma or critical illnessR01GM127596 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2018 to 2021
$1.3M
Targeting the Host Adenosine A2A Receptor to Protect Against Fatal Rickettsiosis Using an Approved Parkinson's Disease DrugR21AI137785 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2018 to 2019
$440k
The role of IL-1 family of cytokines in tick-transmitted ehrlichiosisR21AI144328 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2019 to 2020
$435k
Targeting extracellular tRNA-derived RNA fragments (tRFs) to protect against fatal rickettsiosisR21AI154211 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2020 to 2021
$435k
Inflammasome activation and ehrlichial dissemination in tick vs needle transmissionR03AI142406 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2019 to 2020
$158k
NIAID NIH HHS R01 AI121012NIAID NIH HHS R03 AI142406NIAID NIH HHS R21 AI137785NIAID NIH HHS R21 AI144328NIAID NIH HHS R21 AI154211NIGMS NIH HHS R01 GM127596
6 · The paper itself

Abstract

Spotted fever group rickettsioses (SFRs) are devastating human infections. Vascular endothelial cells (ECs) are the primary targets of rickettsial infection. Edema resulting from EC barrier dysfunction occurs in the brain and lungs in most cases of lethal SFR, but the underlying mechanisms remain unclear. The aim of the study was to explore the potential role of

Indexed as

AnimalsExosomesHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMicroRNAsRickettsiaRickettsia InfectionsMicroRNAsbarrier functionendothelial barrier functionendothelial cellexosomeextracellular vesiclerickettsial infectionspotted fever group rickettsial infection

Identifiers

PMID33975935
PMCPMC8262936
OpenAlexW3160266616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.