ArticleJournal of neurointerventional surgery2022
Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy.
Article in Journal of neurointerventional surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Per-pass analysis of recanalization and good neurological outcome in thrombectomy for stroke: Systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Pooled it
- Effectiveness of diterpene ginkgolides meglumine injection after endovascular therapy for cardioembolic stroke: a randomized controlled trial.Frontiers in pharmacology · 2025Trial
- Arterial wall fragment embolism following balloon-assisted coiling: A case report.Radiology case reports · 2026Article
- Predictors and a Nomogram for Parenchymal Hematoma After Endovascular Thrombectomy in Large Core Ischemic Stroke.CNS neuroscience & therapeutics · 2026Article
- Clinical Outcomes and Factors Associated with Reocclusion after Endovascular Therapy for Intracranial Atherothrombotic Stroke with Large Vessel Occlusion.Clinical neuroradiology · 2026Article
- Adhesion of vessel wall to stentriever during combined technique for mechanical thrombectomy in acute ischemic stroke: A histomorphological study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- AI-driven diagnosis of vulnerable intracranial atherosclerotic plaques using large language models and vision transformers: a multi-center study.European radiology · 2026Article
- Making the invisible visible: integrated visualization and automated quantification of thrombus deformation during mechanical thrombectomy.Frontiers in medical technology · 2026Article
- Is There a Relationship Between the Histopathological Features and Anatomical Locations of Thrombi Obtained During Endovascular Thrombectomy in Acute Ischemic Stroke and Its Comorbid Diseases?Diagnostics (Basel, Switzerland) · 2025Article
- Prognostic Value of Cerebral Hemodynamics Assessment on 24-h Transcranial Color-Coded Doppler Following a Successful Thrombectomy.European journal of neurology · 2025Observational
- In Vitro Assessment of Vascular Injury following Stent Retriever Retraction in Clinically Relevant Endothelialized Silicone Models.AJNR. American journal of neuroradiology · 2025Article
- Radiomics-based machine learning model for predicting clinically ineffective reperfusion in acute ischaemic stroke patients after endovascular treatment.Frontiers in neurology · 2025Article
- Unraveling the Enigma: Correlating Thrombus Histopathology With the Number of Passes in Mechanical Thrombectomy.Cureus · 2025Article
- True first-pass effect in patients undergoing thrombectomy for acute large core strokes.Annals of clinical and translational neurology · 2024Article
- Review: Preclinical Models of Large-Vessel Occlusion Stroke.Stroke (Hoboken, N.J.) · 2024Review
- Article
- Exploring thrombus composition in cerebral venous thrombosis: the first case report with initial insights and implications for treatment advancements.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Prognostic value of recanalization attempts in endovascular therapy for M2 segment middle cerebral artery occlusions.International journal of stroke : official journal of the International Stroke Society · 2024Observational
- Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke.BMC neurology · 2024Article
- Association Between Recanalization Attempts and Functional Outcome After Thrombectomy for Large Ischemic Stroke.Stroke · 2023Article
Corrections and comments
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Authors and funding
40 authors at 12 institutions in 3 countries.
Funding
Abstract
backgroundSeveral animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following MT are difficult to determine.
objectiveTo investigate the occurrence of VWI during MT by histological and immunohistochemical evaluation of AIS clots.
methodsAs part of the multicenter STRIP registry, 277 clots from 237 patients were analyzed using Martius Scarlett Blue stain and immunohistochemistry for CD34 (endothelial cells) and smooth muscle actin (smooth muscle cells).
resultsMT devices used were aspiration catheters (100 cases), stentriever (101 cases), and both (36 cases). VWI was found in 33/277 clots (12%). There was no significant correlation between VWI and MT device. The degree of damage varied from grade I (mild intimal damage, 24 clots), to grade II (relevant intimal and subintimal damage, 3 clots), and III (severe injury, 6 clots). VWI clots contained significantly more erythrocytes (p=0.006*) and less platelets/other (p=0.005*) than non-VWI clots suggesting soft thrombus material.Thrombolysis correlated with a lower rate of VWI (p=0.04*). VWI cases showed a significantly higher number of passes (2 [1-4] vs 1 [1-3], p=0.028*) and poorer recanalization outcome (p=0.01*) than cases without VWI.
conclusionsHistological markers of VWI were present in 12% of AIS thrombi, suggesting that VWI might be related to MT. VWI was associated with soft thrombus consistency, higher number of passes and poorer revascularization outcome. There was no significant correlation between VWI and MT device.
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