Evidence map›Paper›PMID 33975888›Full record

ArticleBMJ global health2021

Why do people purchase antibiotics over-the-counter? A qualitative study with patients, clinicians and dispensers in central, eastern and western Nepal.

Bipin Adhikari, Sunil Pokharel, Shristi Raut, Janak Adhikari, Suman Thapa, Kumar Paudel, Narayan G C, Sandesh Neupane, Sanjeev Raj Neupane, Rakesh Yadav and 5 more

Abstract read
In one paragraph

Article in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bipin AdhikariMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand biopion@gmail.com.ORCID 0000-0001-8981-3910
Sunil PokharelCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-6716-7732
Shristi RautUniversal College of Medical Sciences and Teaching Hospital, Bhairahawa, Nepal.
Janak AdhikariBP Koirala Institute of Health Sciences, Dharan, Nepal.
Suman ThapaPatan Academy of Health Sciences, Patan, Nepal.
Kumar PaudelUniversal College of Medical Sciences and Teaching Hospital, Bhairahawa, Nepal.
Narayan G CUniversal College of Medical Sciences and Teaching Hospital, Bhairahawa, Nepal.
Sandesh NeupaneCountry Coordinating Mechanism, The Global Fund, Ministry of Health and Population, Kathmandu, Nepal.
Sanjeev Raj NeupaneAustralian Federation of AIDS Organisations, Bangkok, Thailand.
Rakesh YadavNepal Public Health Research & Development Centre, Kathmandu, Nepal.
Sirapa ShresthaManmohan Memorial Institute of Health Sciences, Kathmandu, Nepal.
Komal Raj RijalCentral Department of Microbiology, Tribhuvan University, Kirtipur, Nepal.ORCID 0000-0001-6281-8236
Sujan B MarahattaManmohan Memorial Institute of Health Sciences, Kathmandu, Nepal.
Phaik Yeong CheahMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-6327-3266
Christopher PellCentre for Social Science and Global Health, University of Amsterdam, Amsterdam, The Netherlands.

Funding

Wellcome TrustWellcome Trust 220211/Z/20/Z
6 · The paper itself

Abstract

introductionOver-the-counter (OTC) use of antibiotics contributes to the burgeoning rise in antimicrobial resistance (AMR). Drawing on qualitative research methods, this article explores the characteristics of OTC sales of antibiotic in Nepal, its drivers and implications for policy.

methodsData were collected in and around three tertiary hospitals in eastern, western and central Nepal. Using pre-defined guides, a mix of semi-structured interviews and focus group discussions were conducted with dispensers at drug stores, patients attending a hospital and clinicians. Interviews were audio-recorded, translated and transcribed into English and coded using a combination of an inductive and deductive approach.

resultsDrug shops were the primary location where patients engaged with health services. Interactions were brief and transactional: symptoms were described or explicit requests for specific medicine made, and money was exchanged. There were economic incentives for clients and drug stores: patients were able to save money by bypassing the formal healthcare services. Clinicians described antibiotics as easily available OTC at drug shops. Dispensing included the empirical use of broad-spectrum antibiotics, often combining multiple antibiotics, without laboratory diagnostic and drug susceptibility testing. Inappropriately short regimens (2-3 days) were also offered without follow-up. Respondents viewed OTC antibiotic as a convenient alternative to formal healthcare, the access to which was influenced by distance, time and money. Respondents also described the complexities of navigating various departments in hospitals and little confidence in the quality of formal healthcare. Clinicians and a few dispensers expressed concerns about AMR and referred to evadable policies around antibiotics use and poor enforcement of regulation.

conclusionsThe findings point to the need for clear policy guidance and rigorous implementation of prescription-only antibiotics.

Indexed as

Anti-Bacterial AgentsMycobacterium tuberculosisHumansMicrobial Sensitivity TestsNepalQualitative ResearchAnti-Bacterial Agentsdiseasesdisordershealth policyhealth services researchhealth systemsinfectionsinjuriesqualitative study

Identifiers

PMID33975888
PMCPMC8118002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.