Evidence map›Paper›PMID 33975882›Full record

ArticleCancer research2021

Phenotypic Heterogeneity and Metastasis of Breast Cancer Cells.

Lauren A Hapach, Shawn P Carey, Samantha C Schwager, Paul V Taufalele, Wenjun Wang, Jenna A Mosier, Nerymar Ortiz-Otero, Tanner J McArdle, Zachary E Goldblatt, Marsha C Lampi and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 66 citations in OpenAlex.

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  12. Tumor-Tissue Boundaries as Instructive Interfaces in Breast Cancer Cell Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Lauren A HapachNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York.ORCID 0000-0002-9404-8974
Shawn P CareyNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York.
Samantha C SchwagerDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Paul V TaufaleleDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Wenjun WangDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0003-0907-6282
Jenna A MosierDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Nerymar Ortiz-OteroNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York.
Tanner J McArdleSchool of Medicine, Vanderbilt University, Nashville, Tennessee.
Zachary E GoldblattNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York.
Marsha C LampiNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York.
Francois BordeleauDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0002-5114-1757
Jocelyn R MarshallNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York.
Isaac M RichardsonDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Jiahe LiNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York.ORCID 0000-0002-9889-8546
Michael R KingDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.
Cynthia A Reinhart-KingDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee. cynthia.reinhart-king@vanderbilt.edu.
Vanderbilt University · USCornell University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Molecular Determinants of Confined MigrationR01GM131178 · NIGMS · VANDERBILT UNIVERSITY · PI MARKOV, DMITRY · 2019 to 2022
$1.5M
Alternative splicing regulation by extracellular matrix mechanics: a self-tuning tool to control cell microenvironmental adaptation and tumor progressionK99CA212270 · NCI · VANDERBILT UNIVERSITY · PI BORDELEAU, FRANCOIS · 2017 to 2018
$225k
NCI NIH HHS K99 CA212270NCI NIH HHS P30 CA068485NIDDK NIH HHS U24 DK059637NIGMS NIH HHS R01 GM131178
6 · The paper itself

Abstract

Although intratumoral genomic heterogeneity can impede cancer research and treatment, less is known about the effects of phenotypic heterogeneities. To investigate the role of cell migration heterogeneities in metastasis, we phenotypically sorted metastatic breast cancer cells into two subpopulations based on migration ability. Although migration is typically considered to be associated with metastasis, when injected orthotopically

Indexed as

Cell MovementEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticAnimalsAntigens, CDApoptosisBreast NeoplasmsCadherinsCell ProliferationFemaleHumansMiceMice, Inbred NODMice, SCIDNeoplasm MetastasisNeoplastic Cells, CirculatingAntigens, CDCadherinsCDH1 protein, human

Identifiers

PMID33975882
PMCPMC9067366
OpenAlexW3162344820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.