Evidence map›Paper›PMID 33975878›Full record

ArticleImmunoHorizons2021

Roles of Bone Morphogenetic Protein Receptor 1A in Germinal Centers and Long-Lived Humoral Immunity.

Mary M Tomayko, Selda Karaaslan, Begoña Lainez, Laura J Conter, Eunice Song, Srividhya Venkatesan, Yuji Mishina, Mark J Shlomchik

Open access · goldAbstract read
In one paragraph

Article in ImmunoHorizons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mary M TomaykoDepartment of Dermatology, Yale University School of Medicine, New Haven, CT; mary.tomayko@yale.edu.ORCID 0000-0003-1776-7809
Selda KaraaslanDepartment of Dermatology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0001-7542-739X
Begoña LainezDepartment of Dermatology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-3991-3512
Laura J ConterDepartment of Dermatology, Yale University School of Medicine, New Haven, CT.
Eunice SongLaboratory Medicine, Yale University School of Medicine, New Haven, CT.
Srividhya VenkatesanDepartment of Dermatology, Yale University School of Medicine, New Haven, CT.
Yuji MishinaDepartment of Biologic and Material Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI; and.
Mark J ShlomchikDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.ORCID 0000-0002-2152-0959
Yale University · USUniversity of Michigan · USUniversity of Pittsburgh · US

Funding

Murine Memory B Cell Development and FunctionR01AI043603 · NIAID · YALE UNIVERSITY · PI MARK J SHLOMCHIK · 1998 to 2026
$9.7M
Signaling and Selection in Germinal Center B CellsR01AI105018 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARK J SHLOMCHIK · 2014 to 2026
$4.8M
B Cell Memory Regulation by Bone Morphogenetic Protein Receptor 1AR01AI122448 · NIAID · YALE UNIVERSITY · PI TOMAYKO, MARY · 2015 to 2019
$2.2M
Elucidating functional properties of memory B cellsK08AI078533 · NIAID · YALE UNIVERSITY · PI TOMAYKO, MARY · 2008 to 2012
$774k
Murine Memory B Cell Development and FunctionR56AI043603 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2016 to 2016
$609k
NIAID NIH HHS K08 AI078533NIAID NIH HHS R01 AI043603NIAID NIH HHS R01 AI105018NIAID NIH HHS R01 AI122448NIAID NIH HHS R56 AI043603
6 · The paper itself

Abstract

In response to T-dependent Ag, germinal centers (GC) generate bone marrow-resident plasma cells (BMPC) and memory B cells (MBC). In this study, we demonstrate that the bone morphogenetic protein receptor 1A (BMPR1A) signaling pathway, which regulates differentiation and self-renewal in multiple stem cell populations, regulates GC dynamics and resultant establishment of BMPC and MBC. Expression studies using quantitative PCR and novel

Indexed as

AnimalsBone Marrow CellsBone Morphogenetic Protein ReceptorsBone Morphogenetic Protein Receptors, Type IGerminal CenterImmunity, HumoralImmunoglobulin MMemory B CellsMiceMice, Inbred C57BLPlasma CellsBmpr1a protein, mouseBone Morphogenetic Protein ReceptorsBone Morphogenetic Protein Receptors, Type IImmunoglobulin M

Identifiers

PMID33975878
PMCPMC12221147
OpenAlexW3160101861

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.