Evidence map›Paper›PMID 33975819›Full record

ArticleJACC. Cardiovascular imaging2021

Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers.

George Joy, Jessica Artico, Hibba Kurdi, Andreas Seraphim, Clement Lau, George D Thornton, Marta Fontes Oliveira, Robert Daniel Adam, Nikoo Aziminia, Katia Menacho and 21 more

Open access · hybridAbstract read
In one paragraph

Article in JACC. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 10 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 10 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
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  6. ESCMID rapid guidelines for assessment and management of long COVID.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Guideline
  7. Pooled it
  8. Guideline
  9. Pooled it
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  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Prospective electrocardiographic and cardiovascular magnetic resonance alterations in the UK Biobank coronavirus disease 2019 repeat imaging study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  17. Article
  18. Review
  19. Cardiovascular disease and covid-19: A systematic review.International journal of cardiology. Heart & vasculature · 2024
    Review
  20. SARS-CoV-2-specific CD8Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 9 institutions in 4 countries.

George JoyBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Jessica ArticoBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Hibba KurdiBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Andreas SeraphimBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Clement LauBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
George D ThorntonBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Marta Fontes OliveiraBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Cardiology Department, University Hospital Centre of Porto, Porto, Portugal.
Robert Daniel AdamBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Nikoo AziminiaBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom.
Katia MenachoBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Liza ChackoInstitute of Cardiovascular Science, University College London, London, United Kingdom; National Amyloidosis Centre, Division of Medicine, University College London, London, United Kingdom; Royal Free London NHS Foundation Trust, Pond Street, London, United Kingdom.
James T BrownInstitute of Cardiovascular Science, University College London, London, United Kingdom; National Amyloidosis Centre, Division of Medicine, University College London, London, United Kingdom; Royal Free London NHS Foundation Trust, Pond Street, London, United Kingdom.
Rishi K PatelInstitute of Cardiovascular Science, University College London, London, United Kingdom; National Amyloidosis Centre, Division of Medicine, University College London, London, United Kingdom; Royal Free London NHS Foundation Trust, Pond Street, London, United Kingdom.
Hunain ShiwaniBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Anish BhuvaBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Joao B AugustoBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom; Cardiology Department, Hospital Prof Doutor Fernando Fonseca Amadora, Portugal.
Mervyn AndiapenWilliam Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Aine McKnightBlizard Institute, Queen Mary University of London, London, United Kingdom.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, United Kingdom.
Iain PierceBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Timothée EvainImageens, Paris, France.
Gabriella CapturInstitute of Cardiovascular Science, University College London, London, United Kingdom; Royal Free London NHS Foundation Trust, Pond Street, London, United Kingdom.
Rhodri H DaviesBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
John P GreenwoodLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, and Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
Marianna FontanaInstitute of Cardiovascular Science, University College London, London, United Kingdom; National Amyloidosis Centre, Division of Medicine, University College London, London, United Kingdom; Royal Free London NHS Foundation Trust, Pond Street, London, United Kingdom.
Peter KellmanNational Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, USA.
Erik B SchelbertUPMC CMR Center, UPMC, Pittsburgh, Pennsylvania, USA.
Thomas A TreibelBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Charlotte ManistyBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
James C MoonBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom. Electronic address: j.moon@ucl.ac.uk.
COVIDsortium Investigators
Barts Health NHS Trust · GBUniversity College London · GBRoyal Free London NHS Foundation Trust · GBWilliam Harvey Research Institute · GBCarol Davila University of Medicine and Pharmacy · ROCUF Porto Hospital · PTLeeds Teaching Hospitals NHS Trust · GBNational Heart Lung and Blood Institute · USQueen Mary University of London · GB

Funding

Gadgetron Global Network and Intelligence Computing: Clinical Imaging Application Development and Software InfrastructureZIAHL006214 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KELLMAN, PETER · 2016 to 2025
$7.3M
Gadgetron Global Network and Artificial Intelligence Powered Cardiac ImagingZIAHL006242 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KELLMAN, PETER · 2019 to 2023
$2.2M
British Heart Foundation FS/CRTF/21/24128British Heart Foundation SP/20/2/34841
6 · The paper itself

Abstract

objectivesThe purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome-coronavirus-2 infection.

backgroundConcern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease.

methodsParticipants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology assessment over 4 months, with seroconversion in 21.5% (n = 157). At 6 months post-infection, 74 seropositive and 75 age-, sex-, and ethnicity-matched seronegative control subjects were recruited for cardiovascular phenotyping (comprehensive phantom-calibrated cardiovascular magnetic resonance and blood biomarkers). Analysis was blinded, using objective artificial intelligence analytics where available.

resultsA total of 149 subjects (mean age 37 years, range 18 to 63 years, 58% women) were recruited. Seropositive infections had been mild with case definition, noncase definition, and asymptomatic disease in 45 (61%), 18 (24%), and 11 (15%), respectively, with 1 person hospitalized (for 2 days). Between seropositive and seronegative groups, there were no differences in cardiac structure (left ventricular volumes, mass, atrial area), function (ejection fraction, global longitudinal shortening, aortic distensibility), tissue characterization (T

conclusionsCardiovascular abnormalities are no more common in seropositive versus seronegative otherwise healthy, workforce representative individuals 6 months post-mild severe acute respiratory syndrome-coronavirus-2 infection.

Indexed as

Cardiovascular AbnormalitiesCOVID-19AdolescentAdultArtificial IntelligenceCase-Control StudiesContrast MediaFemaleGadoliniumHealth PersonnelHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardiumPredictive Value of TestsContrast MediaGadoliniumcardiovascular magnetic resonanceCOVID-19late gadolinium enhancementmyocardial edemamyocarditisSARS-CoV-2troponin

Identifiers

PMID33975819
PMCPMC8105493
OpenAlexW3162039699

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.