ReviewHead & face medicine2021
COVID-19 and periodontitis: reflecting on a possible association.
Review in Head & face medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05950230 (A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Current Landscape of the Interrelationship Between Periodontitis, Type 2 Diabetes Mellitus, and COVID-19.International journal of molecular sciences · 2025Review
- Periodontal Disease Elevates IL-6 Levels During Initial Symptoms of COVID-19.Diagnostics (Basel, Switzerland) · 2025Article
- Relationship Between Periodontitis and the Severity of Lung Infection Caused by COVID-19: A Case-Control Observational Study.Health science reports · 2025Article
- Relationship between periodontitis, type 2 diabetes mellitus and COVID-19 disease: a narrative review.Frontiers in cellular and infection microbiology · 2025Review
- The Evaluation of Oral Health in Patients Undergoing Dental Treatment During the COVID-19 Pandemic.Journal of clinical medicine · 2024Article
- The role of viruses in oral mucosal lesions.Periodontology 2000 · 2024Review
- Herpesviruses and SARS-CoV-2: Viral Association with Oral Inflammatory Diseases.Pathogens (Basel, Switzerland) · 2024Review
- Unraveling the Link between Periodontitis and Coronavirus Disease 2019: Exploring Pathogenic Pathways and Clinical Implications.Biomedicines · 2023Review
- Association between periodontal diseases and COVID-19 infection: a case-control study with a longitudinal arm.Odontology · 2023Article
- Relationship between periodontitis and COVID-19: A bidirectional two-sample Mendelian randomization study.Health science reports · 2023Article
- Oral and systemic health: is there a "new" link with COVID-19?Clinical oral investigations · 2023Review
- Relationship between the Social Development Index and Self-Reported Periodontal Conditions.Healthcare (Basel, Switzerland) · 2023Article
- Periodontitis and COVID-19: Immunological Characteristics, Related Pathways, and Association.International journal of molecular sciences · 2023Review
- Periodontal disease and COVID-19: Prognosis and potential pathways of association in their pathogenesis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2023Review
- Diabetes Prevention and Measures to Ensuring a Healthy Lifestyle during COVID-19 Pandemic and after.Korean journal of family medicine · 2023Article
- Association between Periodontitis and COVID-19 Based on Severity Scores of HRCT Chest Scans.Dentistry journal · 2022Article
- Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review.Frontiers in oral health · 2022Review
- Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study.Journal of translational medicine · 2021Article
- Assessment of Oral Microbiome Changes in Healthy and COVID-19-Affected Pregnant Women: A Narrative Review.Microorganisms · 2021Review
- Oral Health and Teledentistry Interest during the COVID-19 Pandemic.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated a relationship between the severe clinical course of COVID-19 and other chronic diseases such as: cardiovascular disease, hypertension, diabetes mellitus, obesity and chronic renal disease. It may be possible to extend this association to a common and chronic oral disease in adults: periodontitis. Alternatively, the latter could be simply related to the systemic chronic diseases cited above, as already observed in the non-COVID-19 literature. In order to provide an overview and their opinion, the authors in this perspective article will report and discuss the most recent references of interest relating to COVID-19 and periodontitis pathophysiology. Within such a narrative review, the authors will hypothesize that the association between chronic periodontitis and COVID-19 could exist via two pathways: a direct link, through the ACEII and CD147 receptors used by the virus to infect the cells, which would occur in greater numbers in cases of periodontitis (thereby favoring a SARS-CoV-2 infection); and/or an indirect pathway involving the overexpression of inflammatory molecules, especially IL-6 and IL-17. An expression of the latter has been found to play a role in periodontitis, in addition to severe cases of COVID-19, although it is still unclear if it plays a direct role in the worsening of the clinical course.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.