SynthesisBMC psychiatry2021
Lower regional grey matter in alcohol use disorders: evidence from a voxel-based meta-analysis.
Synthesis in BMC psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Grey matter volume differences in pediatric obsessive-compulsive disorder: a meta-analysis of voxel-based morphometry studies.BMC psychiatry · 2025Pooled it
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Pooled it
- Breaking the norm: population-scale deviations of brain structure in depression and anxiety.Molecular psychiatry · 2026Article
- Distinct structural abnormalities in obsessive-compulsive and alcohol use disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- 2D:4D digit ratio and brain volumes in alcohol use disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Far infrared intervention on brain changes in patients with alcohol dependence: a pilot longitudinal MRI study.Frontiers in psychiatry · 2026Article
- MRI assessment of intrinsic neural timescales in male alcohol use disorder patients.Frontiers in psychiatry · 2026Article
- A Meta-Analysis of Task-Based fMRI Studies on Alcohol Use Disorder.Brain sciences · 2025Review
- Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers.Addiction biology · 2025Article
- Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers.NeuroImage. Clinical · 2025Article
- Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence fromFrontiers in psychology · 2025Article
- Volumetric and cortical thickness alterations in alcohol dependence: evidence of accelerated brain aging and clinical correlations.Frontiers in psychiatry · 2025Article
- Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders.Current topics in behavioral neurosciences · 2025Review
- Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024Article
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious research using whole-brain neuroimaging techniques has revealed structural differences of grey matter (GM) in alcohol use disorder (AUD) patients. However, some of the findings diverge from other neuroimaging studies and require further replication. The quantity of relevant research has, thus far, been limited and the association between GM and abstinence duration of AUD patients has not yet been systematically reviewed.
methodsThe present research conducted a meta-analysis of voxel-based GM studies in AUD patients published before Jan 2021. The study utilised a whole brain-based d-mapping approach to explore GM changes in AUD patients, and further analysed the relationship between GM deficits, abstinence duration and individual differences.
resultsThe current research included 23 studies with a sample size of 846 AUD patients and 878 controls. The d-mapping approach identified lower GM in brain regions including the right cingulate gyrus, right insula and left middle frontal gyrus in AUD patients compared to controls. Meta-regression analyses found increasing GM atrophy in the right insula associated with the longer mean abstinence duration of the samples in the studies in our analysis. GM atrophy was also found positively correlated with the mean age of the samples in the right insula, and positively correlated with male ratio in the left middle frontal gyrus.
conclusionsGM atrophy was found in the cingulate gyrus and insula in AUD patients. These findings align with published meta-analyses, suggesting they are potential deficits for AUD patients. Abstinence duration, age and gender also affect GM atrophy in AUD patients. This research provides some evidence of the underlying neuroanatomical nature of AUD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.