ArticleBiomedical engineering online2021
Understanding the influence of left ventricular assist device inflow cannula alignment and the risk of intraventricular thrombosis.
Article in Biomedical engineering online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 24 citations in OpenAlex.
- Mechanical and Hemocompatibility Assessment of Selected Technologies for Prosthesis Connection with the Outflow Cannula Graft of the RH PEDJournal of clinical medicine · 2025Article
- Relapsing low-flow alarms due to suboptimal alignment of the left ventricular assist device inflow cannula.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Article
- Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation.PLoS computational biology · 2022Article
- Editorial: Computational biomechanics for ventricle-arterial dysfunction and remodeling in heart failure, Volume II.Frontiers in physiology · 2022Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundAdverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in the implanted device orientation. A severely dilated pulsatile patient-specific left ventricle, modelled with computational fluid dynamics, was utilised to identify the risk of thrombosis for five cannulation angles. With respect to the inflow cannula axis directed towards the mitral valve, the other angles were 25° and 20° towards the septum and 20° and 30° towards the free wall.
resultsInflow cannula angulation towards the free wall resulted in longer blood residence time within the ventricle, slower ventricular washout and reduced pulsatility indices along the septal wall. Based on the model, the ideal inflow cannula alignment to reduce the risk of thrombosis was angulation towards the mitral valve and up to parallel to the septum, avoiding the premature clearance of incoming blood.
conclusionsThis study indicates the potential effects of inflow cannulation angles and may guide optimised implantation configurations; however, the ideal approach will be influenced by other patient factors and is suspected to change over the course of support.
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