Evidence map›Paper›PMID 33975513›Full record

ArticleBioengineered2021

Circulating microRNA profile unveils mechanisms of action of acitretin for psoriasis vulgaris.

Lin Chen, Jie Li, Ying Yao, Shanlong Wang, Shuangjin Zheng, Xinggang Ju, Bin Zhang

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Psoriasis.Nature reviews. Disease primers · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lin ChenDepartment of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China.ORCID 0000-0003-3087-1125
Jie LiDepartment of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China.
Ying YaoDepartment of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China.
Shanlong WangDepartment of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China.
Shuangjin ZhengDepartment of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China.
Xinggang JuDepartment of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China.
Bin ZhangDepartment of Dermatology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, China.
Henan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis vulgaris is a common chronic and recurrent inflammatory skin disease. In clinical practice, acitretin is the first-line treatment drug for psoriasis vulgaris. MicroRNAs (miRNAs) play a vital role in the initiation and development of psoriasis vulgaris. However few studies focused on the mechanisms of acitretin in the treatment of psoriasis vulgaris from the perspective of miRNAs. Here, the expression profiles of circulating miRNAs in the plasma of 12 patients with psoriasis vulgaris before and after acitretin treatment were sequenced. Three miRNAs (miR-146a-5p, miR-122-5p and miR-21-5p) were identified using expression pattern analysis, and the levels were significantly decreased after acitretin treatment (

Indexed as

AcitretinAdultArea Under CurveCirculating MicroRNADown-RegulationFemaleGene Expression ProfilingHaCaT CellsHumansMalePsoriasisReproducibility of ResultsROC CurveSignal TransductionAcitretinCirculating MicroRNAacitretinJAK-STATMAPKmiRNANF-ΚBPsoriasis vulgaris

Identifiers

PMID33975513
PMCPMC8806620
OpenAlexW3162313708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.