Evidence map›Paper›PMID 33975485›Full record

ArticleBiology letters2021

Adaptation at different points along antibiotic concentration gradients.

Mato Lagator, Hildegard Uecker, Paul Neve

Open access · hybridAbstract read
In one paragraph

Article in Biology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Microbiology (Reading, England) · 2025
    Review
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  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 5 countries.

Mato LagatorIST Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Hildegard UeckerIST Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Paul NeveBiointeractions and Crop Protection Department, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.
Institute of Science and Technology Austria · ATUniversity of Copenhagen · DK

Funding

Wellcome TrustWellcome Trust 216779/Z/19/Z
6 · The paper itself

Abstract

Antibiotic concentrations vary dramatically in the body and the environment. Hence, understanding the dynamics of resistance evolution along antibiotic concentration gradients is critical for predicting and slowing the emergence and spread of resistance. While it has been shown that increasing the concentration of an antibiotic slows resistance evolution, how adaptation to one antibiotic concentration correlates with fitness at other points along the gradient has not received much attention. Here, we selected populations of

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialAdaptation, PhysiologicalEscherichia coliMutationAnti-Bacterial Agentsadaptationantibiotic resistancedrug dose

Identifiers

PMID33975485
PMCPMC8113895
OpenAlexW3163773924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.