Evidence map›Paper›PMID 33975459›Full record

ArticleTissue engineering. Part A2021

Surface Roughness of Titanium Orthopedic Implants Alters the Biological Phenotype of Human Mesenchymal Stromal Cells.

Eric A Lewallen, William H Trousdale, Roman Thaler, Jie J Yao, Wei Xu, Janet M Denbeigh, Asha Nair, Jean-Pierre Kocher, Amel Dudakovic, Daniel J Berry and 4 more

Abstract read
In one paragraph

Article in Tissue engineering. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eric A LewallenDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
William H TrousdaleDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Roman ThalerDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Jie J YaoDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Wei XuDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-6030-0668
Janet M DenbeighDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Asha NairDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Jean-Pierre KocherDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Amel DudakovicDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Daniel J BerryDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Robert C CohenDigital, Robotics, and Enabling Technologies, Stryker Orthopedics, Mahwah, New Jersey, USA.
Matthew P AbdelDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
David G LewallenDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Andre J van WijnenDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-4458-0946

Funding

Musculoskeletal Research Training ProgramT32AR056950 · NIAMS · MAYO CLINIC ROCHESTER · PI Jennifer J Westendorf · 2009 to 2026
$7.0M
Molecular Control of Bone FormationR01AR049069 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WESTENDORF, JENNIFER J · 2003 to 2021
$5.8M
Epigenetic control of osteoblast differentiationF32AR066508 · NIAMS · MAYO CLINIC ROCHESTER · PI DUDAKOVIC, AMEL · 2015 to 2017
$185k
Biological enhancement of metal implant materials in orthopedicsF32AR068154 · NIAMS · MAYO CLINIC ROCHESTER · PI LEWALLEN, ERIC A · 2016 to 2016
$54k
NIAMS NIH HHS F32 AR066508NIAMS NIH HHS F32 AR068154NIAMS NIH HHS R01 AR049069NIAMS NIH HHS T32 AR056950
6 · The paper itself

Abstract

Metal orthopedic implants are largely biocompatible and generally achieve long-term structural fixation. However, some orthopedic implants may loosen over time even in the absence of infection.

Indexed as

Mesenchymal Stem CellsTitaniumAlloysAnimalsHumansOsseointegrationPhenotypeProstheses and ImplantsSurface PropertiesAlloysTitaniumcell adhesionmicroenvironmentstem cell behaviorsurface modificationtitaniumtitanium alloy (TiAl6V4)

Identifiers

PMID33975459
PMCPMC8742309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.