ArticleCirculation research2021
Inherited Variants in
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In one paragraph
Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Exploring associations between estrogen and gene candidates identified by coronary artery disease genome-wide association studies.Frontiers in cardiovascular medicine · 2025Pooled it
- Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity.Development (Cambridge, England) · 2026Article
- Genetic testing in individuals with extreme HDL-C levels: Diagnostic yield and clinical implications from the Tromsø Study.PloS one · 2026Article
- Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environmental epigenetics · 2026Article
- High-density lipoproteins. Part 2. Impact of disease states on functionality.American journal of preventive cardiology · 2025Article
- Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host.Journal of virology · 2025Article
- Dysfunctional high-density lipoprotein: an updated review.Frontiers in cardiovascular medicine · 2025Review
- Global, regional, and national burden of early-onset ischemic heart disease: trends and projections among adults aged 15-44 years from 1990 to 2046.Frontiers in cardiovascular medicine · 2025Article
- SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease.Cardiovascular drugs and therapy · 2024Review
- High-Density Lipoprotein-Associated Paraoxonase-1 (PON-1) and Scavenger Receptor Class B Type 1 (SRB-1) in Coronary Artery Disease: Correlation with Disease Severity.Journal of clinical medicine · 2024Article
- Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition.Circulation · 2024Article
- Rare and common coding variants in lipid metabolism-related genes and their association with coronary artery disease.BMC cardiovascular disorders · 2024Article
- Exploring shared therapeutic targets in diabetic cardiomyopathy and diabetic foot ulcers through bioinformatics analysis.Scientific reports · 2024Article
- The relationship between early-onset coronary artery disease and familial hypercholesterolemia: a cohort study based on the Hakka population in Meizhou, China.American journal of translational research · 2024Article
- SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor.Current atherosclerosis reports · 2022Review
- Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk.Frontiers in pharmacology · 2022Article
- High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Good Cholesterol Gone Bad? HDL and COVID-19.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 1 country.
Sara N KoenigDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Holly C SucharskiDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Elizabeth M JoseDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Emma K DudleyDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Francesca MadiaiDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Omer CavusDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Aaron D ArgallDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Jordan L WilliamsDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Nathaniel P MurphyDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Caullin B R KeithDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Mona El RefaeyDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Richard J GuminaDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Konstantinos D BoudoulasRoss Heart Hospital, The Ohio State University College of Medicine and Wexner Medical Center (F.M., R.J.G., K.D.B., M.W.M., G.S., S.A.S., E.A.B., K.M.Z., E.L.M., P.J.M.), The Ohio State University, Columbus.
M Wesley MilksRoss Heart Hospital, The Ohio State University College of Medicine and Wexner Medical Center (F.M., R.J.G., K.D.B., M.W.M., G.S., S.A.S., E.A.B., K.M.Z., E.L.M., P.J.M.), The Ohio State University, Columbus.
Gbemiga SofoworaRoss Heart Hospital, The Ohio State University College of Medicine and Wexner Medical Center (F.M., R.J.G., K.D.B., M.W.M., G.S., S.A.S., E.A.B., K.M.Z., E.L.M., P.J.M.), The Ohio State University, Columbus.
Sakima A SmithDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Thomas J HundDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Nathan T WrightDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA (N.T.W.).
Elisa A BradleyDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Karolina M ZarebaRoss Heart Hospital, The Ohio State University College of Medicine and Wexner Medical Center (F.M., R.J.G., K.D.B., M.W.M., G.S., S.A.S., E.A.B., K.M.Z., E.L.M., P.J.M.), The Ohio State University, Columbus.
Loren E WoldDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Ernest L MazzaferriDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Peter J MohlerDorothy M. Davis Heart and Lung Research Institute and Frick Center for Heart Failure and Arrhythmia Research (S.N.K., H.C.S., E.M.J., E.K.D., F.M., O.C., A.D.A., J.L.W., N.P.M., C.B.R.K., M.E.R., R.J.G., S.A.S., T.J.H., E.A.B., L.E.W., E.L.M., P.J.M.), The Ohio State University, Columbus.
Heart Rhythm Society · USThe Ohio State University Wexner Medical Center · USJames Madison University · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MDefining novel mechanisms for human arrhythmiaR35HL135754 · NHLBI · OHIO STATE UNIVERSITY · PI MOHLER, PETER J. · 2017 to 2023
$6.0MMechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's DiseaseR01AG057046 · NIA · OHIO STATE UNIVERSITY · PI COMBS, COLIN K, DEL MONTE, FEDERICA · 2017 to 2021
$4.0MDefining novel mechanisms for regulation of atrial INa and arrhythmiasR01HL134824 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY, MOHLER, PETER J. · 2017 to 2020
$3.0MUniversity of Arizona's Initiative for Maximizing Student Development (IMSD)T32GM139779 · NIGMS · UNIVERSITY OF ARIZONA · PI FRANS E TAX · 2022 to 2026
$2.9MTraining in Congenital and Acquired Heart DiseaseT32HL098039 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU, MOHLER, PETER J. · 2009 to 2019
$2.5MGraduate Training in Biochemistry and Molecular BiologyT32GM136536 · NIGMS · UNIVERSITY OF ARIZONA · PI Andrew Paul Capaldi, FRANS E TAX · 2020 to 2026
$2.4MEctonucleotidases in ischemic heart diseaseR01HL127442 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GUMINA, RICHARD J · 2017 to 2021
$2.1MDefining the Impact of E-Cigarettes on Cardiac PathophysiologyR01HL139348 · NHLBI · OHIO STATE UNIVERSITY · PI WOLD, LOREN EUGENE · 2017 to 2020
$1.9MTranslational Candidate-Gene Studies of Simvastatin-Induced Myopathy in African AmericansR01MD011307 · NIMHD · OHIO STATE UNIVERSITY · PI SMITH, SAKIMA AHMAD · 2017 to 2021
$1.9MCaMKII-dependent regulation of cardiac excitabilityR01HL114893 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2012 to 2016
$1.9MSpectrin-based regulation of cardiac remodeling and heart failureR01HL135096 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2017 to 2020
$1.6MNCI NIH HHS P30 CA016058NHLBI NIH HHS F30 HL137325NHLBI NIH HHS K08 HL135437NHLBI NIH HHS K08 HL148701NHLBI NIH HHS K99 HL146969NHLBI NIH HHS R00 HL146969NHLBI NIH HHS R01 HL114893NHLBI NIH HHS R01 HL127442NHLBI NIH HHS R01 HL134824NHLBI NIH HHS R01 HL135096NHLBI NIH HHS R01 HL139348NHLBI NIH HHS R13 HL154524NHLBI NIH HHS R35 HL135754NHLBI NIH HHS T32 HL098039NIA NIH HHS R01 AG057046NIGMS NIH HHS T32 GM136536NIGMS NIH HHS T32 GM139779NIMHD NIH HHS R01 MD011307NIOSH CDC HHS U01 OH012056
Abstract
[Figure: see text].
Indexed as
Genetic VariationAdultAge of OnsetAnimalsCoronary Artery DiseaseExome SequencingFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHEK293 CellsHepatocytesHep G2 CellsHeredityHeterozygoteHumansInduced Pluripotent Stem CellsSCARB1 protein, humanScarb1 protein, mouseScavenger Receptors, Class Bcholesterol, high-density lipoproteincoronary diseasedyslipidemiageneticshumanphysiology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.