Evidence map›Paper›PMID 33975093›Full record

ArticlePsychiatry research2021

Specialty knowledge and competency standards for pharmacotherapy for adult obsessive-compulsive disorder.

Christopher Pittenger, Brian P Brennan, Lorrin Koran, Carol A Mathews, Gerald Nestadt, Michele Pato, Katharine A Phillips, Carolyn I Rodriguez, H Blair Simpson, Petros Skapinakis and 2 more

Open access · greenAbstract read
In one paragraph

Article in Psychiatry research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 12 institutions in 3 countries.

Christopher PittengerDepartment of Psychiatry and Yale Child Study Center, Yale University School of Medicine, New Haven, CT, United States. Electronic address: christopher.pittenger@yale.edu.
Brian P BrennanBiological Psychiatry Laboratory and Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
Lorrin KoranDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States.
Carol A MathewsDepartment of Psychiatry, University of Florida, Gainesville, FL, United States.
Gerald NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Michele PatoInstitute for Genomic Health and Department of Psychiatry, SUNY Downstate College of Medicine, Brooklyn, NY, United States.
Katharine A PhillipsDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, and Department of Psychiatry, Weill Cornell Medical College, New York, NY, United States.
Carolyn I RodriguezDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
H Blair SimpsonDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States; Office of Mental Health, Research Foundation for Mental Hygiene, New York Psychiatric Institute, New York, NY, United States.
Petros SkapinakisDepartment of Psychiatry, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Dan J SteinDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Eric A StorchMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States.
Baylor College of Medicine · USCornell University · USHarvard University · USJohns Hopkins University · USResearch Foundation For Mental Hygiene · USStanford University · USSUNY Downstate Health Sciences University · USUniversity of Cape Town · ZAUniversity of Florida · USUniversity of Ioannina · GRVA Palo Alto Health Care System · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Individually targeted neuromodulation for contamination-based OCDR61MH121640 · NIMH · MCLEAN HOSPITAL · PI BRENNAN, BRIAN P. · 2021 to 2022
$2.1M
Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive DisorderK24MH121571 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2020 to 2024
$900k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K24 MH121571NIMH NIH HHS R61 MH121640
6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) affects approximately one person in 40 and causes substantial suffering. Evidence-based treatments can benefit many; however, optimal treatment can be difficult to access. Diagnosis is frequently delayed, and pharmacological and psychotherapeutic interventions often fail to follow evidence-based guidelines. To ameliorate this distressing situation, the International OCD Accreditation Task Force of the Canadian Institute for Obsessive-Compulsive Disorders has developed knowledge and competency standards for specialized treatments for OCD through the lifespan. These are foundational to evidence-based practice and will form the basis for upcoming ATF development of certification/accreditation programs. Here, we present specialty standards for the pharmacological treatment of adult OCD. We emphasize the importance of integrating pharmacotherapy with clear diagnosis, appreciation of complicating factors, and evidence-based cognitive behavioral therapy. Clear evidence exists to inform first- and second-line pharmacological treatments. In disease refractory to these initial efforts, multiple strategies have been investigated, but the evidence is more equivocal. These standards summarize this limited evidence to give the specialist practitioner a solid basis on which to make difficult decisions in complex cases. It is hoped that further research will lead to development of a clear, multi-step treatment algorithm to support each step in clinical decision-making.

Indexed as

Cognitive Behavioral TherapyObsessive-Compulsive DisorderAdultCanadaCompulsive Personality DisorderHumansKnowledgeSelective Serotonin Reuptake InhibitorsSelective Serotonin Reuptake InhibitorsaugmentationcomorbidityObsessive-compulsive disorder (OCD)pharmacotherapyselective serotonin reuptake inhibitors (SSRIs)treatment

Identifiers

PMID33975093
PMCPMC8536398
OpenAlexW3134948733

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.