ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2021
Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Multimodal protective and susceptibility clusters in paediatric atopic dermatitis: A machine learning-based, data-driven observational study.PLoS medicine · 2026Observational
- Activation of MyD88/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin.JID innovations : skin science from molecules to population health · 2026Article
- Chemokine ligand-receptor interactions as potential therapeutic targets for atopic dermatitis: from basic to clinical research.Frontiers in allergy · 2026Review
- A multi-strain human skin microbiome model provides a testbed for disease modeling.Frontiers in microbiomes · 2025Article
- Review
- Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis.International journal of molecular sciences · 2023Article
- The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Increased Interleukin-36β Expression Promotes Angiogenesis in Japanese Atopic Dermatitis.International journal of molecular sciences · 2023Article
- Phenotypes, endotypes and genotypes of atopic dermatitis and allergy in populations of African ancestry on the continent and diaspora.Frontiers in allergy · 2023Review
- CCL13 and human diseases.Frontiers in immunology · 2023Review
- Biomarkers in atopic dermatitis and psoriasis-a Delphi-based guide through the jungle?Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Dermatology: how to manage atopic dermatitis in patients with skin of colour.Drugs in context · 2022Review
- Prognostic biomarker MCP-4 triggers epithelial-mesenchymal transitionFrontiers in oncology · 2022Article
- The Role of T Helper 22 Cells in Dermatological Disorders.Frontiers in immunology · 2022Review
- Identification of Effective Diagnostic Biomarkers and Immune Cell Infiltration in Atopic Dermatitis by Comprehensive Bioinformatics Analysis.Frontiers in molecular biosciences · 2022Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundAtopic dermatitis (AD) is a common disease, with particularly high prevalence found in Africa. It is increasingly recognized that patients with AD of different ethnic backgrounds have unique molecular signatures in the skin, potentially accounting for treatment response variations. Nevertheless, the skin profile of patients with AD from Africa is unknown, hindering development of new treatments targeted to this patient population.
objectiveTo characterize the skin profile of patients with AD from Africa.
methodsGene expression studies, including RNA sequencing (using threshold of fold change of >2 and false discovery rate of <0.05) and real-time polymerase chain reaction, were performed on skin biopsies of Tanzanian patients with moderate-to-severe AD and controls.
resultsTanzanian AD skin presented robust up-regulations of multiple key mediators of both T helper 2 (T
conclusionThe skin phenotype of Tanzanian patients with AD is consistent with that of African Americans, exhibiting dominant T
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