Evidence map›Paper›PMID 33974975›Full record

ReviewBiochimica et biophysica acta. Molecular and cell biology of lipids2021

Lipid diversity in clostridia.

Ziqiang Guan, Howard Goldfine

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Frontiers in microbiology · 2024
    Article
  6. Article
  7. Bacterial lipid biophysics and membrane organization.Current opinion in microbiology · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Plasmalogens in bacteria, sixty years on.Frontiers in molecular biosciences · 2022
    Review
  12. Microbial Musings - May 2021.Microbiology (Reading, England) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ziqiang GuanDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, United States of America.
Howard GoldfineDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, United States of America. Electronic address: goldfinh@pennmedicine.upenn.edu.
Duke Medical Center · USUniversity of Pennsylvania · US

Funding

STEROL LIPIDSU54GM069338 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 2003 to 2013
$72.2M
Adaptive alterations of lipids in mitis group streptococciR01AI148366 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI GUAN, ZIQIANG, PALMER, KELLI LEA · 2020 to 2024
$2.5M
Adaptive Alterations of Lipids in Streptococcus MitisR56AI139105 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI GUAN, ZIQIANG, PALMER, KELLI LEA · 2019 to 2019
$479k
NIAID NIH HHS R01 AI148366NIAID NIH HHS R56 AI139105NIGMS NIH HHS U54 GM069338
6 · The paper itself

Abstract

Studies of the lipidomes of twenty-one species of clostridia have revealed considerable diversity. Even among those species now defined as Clostridium sensu stricto, which are related to Clostridium butyricum, the type species, lipid analysis has shown that a number of distinct clades have characteristic polar lipids. All species of Clostridium sensu stricto have phosphatidylethanolamine, phosphatidylglycerol and cardiolipin which are present as all acyl or alk-1'-enyl acyl (plasmalogen) species. In addition, almost every clade has specialized polar lipids. For example, the group closely related to Clostridium beijerinckii and several other solventogenic species has glycerol acetals of plasmenylethanolamine, which protects the membrane bilayer arrangement when the lipids are highly unsaturated or in the presence of solvents. The group related to Clostridium novyi has aminoacyl-phosphatidylglycerol, which protects these pathogens from cationic antimicrobial peptides (CAMPs) of innate immunity. Clostridium botulinum species, which fall into several groups, align with these clades, and have the same specific lipids. This review will present the current state of knowledge on clostridial lipids.

Indexed as

ClostridiumCardiolipinsLipid MetabolismLipidomicsLipidsPhosphatidylethanolaminesPhosphatidylglycerolsCardiolipinsLipidsPhosphatidylethanolaminesPhosphatidylglycerolsClostridiumGlycosyldiradylglycerols phospholipidsPlasmalogensTaxonomy

Identifiers

PMID33974975
PMCPMC8238869
OpenAlexW3161868939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.