Evidence map›Paper›PMID 33974434›Full record

ArticleJournal of medicinal chemistry2021

Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in

Yukiko Miyamoto, Shubhangi Aggarwal, Jeff Joseph A Celaje, Sozaburo Ihara, Jonathan Ang, Dmitry B Eremin, Kirkwood M Land, Lisa A Wrischnik, Liangfang Zhang, Valery V Fokin and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. An Electrochemical Study of Key Catalytically Active Gold Complexes.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yukiko MiyamotoDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Shubhangi AggarwalDepartment of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California 90089, United States.
Jeff Joseph A CelajeDepartment of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California 90089, United States.
Sozaburo IharaDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Jonathan AngDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Dmitry B EreminDepartment of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0003-2946-5293
Kirkwood M LandDepartment of Biological Sciences, University of the Pacific, Stockton, California 95211, United States.
Lisa A WrischnikDepartment of Biological Sciences, University of the Pacific, Stockton, California 95211, United States.
Liangfang ZhangDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-0637-0654
Valery V FokinDepartment of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0001-7323-2177
Lars EckmannDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-7987-8742
University of California San Diego · USUniversity of Southern California · USUniversity of the Pacific · US

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
Selective proteasome inhibitors for trichomoniasisR21AI146387 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKMANN, LARS, O'DONOGHUE, ANTHONY JOHN · 2019 to 2020
$433k
Gold Compounds for the Topical Treatment of TrichomoniasisR21AI119459 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKMANN, LARS · 2015 to 2016
$424k
NIAID NIH HHS R21 AI119459NIAID NIH HHS R21 AI146387NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntiprotozoal AgentsCell SurvivalCoordination ComplexesDisease Models, AnimalDrug ResistanceFemaleGoldHeLa CellsHumansMiceMice, Inbred BALB CParasitic Sensitivity TestsPhosphinesProtein IsoformsStructure-Activity RelationshipAntiprotozoal AgentsCoordination ComplexesGoldPhosphinesProtein IsoformsThioredoxin-Disulfide Reductase

Identifiers

PMID33974434
PMCPMC9309012
OpenAlexW3162895154

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.