Evidence map›Paper›PMID 33974241›Full record

ArticleGenes & genomics2021

Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression.

Aimei Chen, Zhiqiang Liu, Quanyan Wu, Hailin Li

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Aimei ChenDepartment of Chinese Traditional Medicine, Weifang Yidu Central Hospital, Weifang, 262500, Shandong, China.
Zhiqiang LiuDepartment of Chinese Traditional Medicine, Weifang Yidu Central Hospital, Weifang, 262500, Shandong, China.
Quanyan WuDepartment of Chinese Traditional Medicine, Weifang Yidu Central Hospital, Weifang, 262500, Shandong, China.
Hailin LiDepartment of General Surgery, Qilu Hospital of Shandong University, #107 Wenhua Road, Jinan, 250012, Shandong, China. a622463366@yeah.net.
Yidu Central Hospital of Weifang · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisheveled-associated activator of morphogenesis (DAAM) family, including DAAM1 and DAAM2, is key regulators in Wnt signaling pathway. Although the oncogenic role of Wnt signaling pathway in colorectal cancer (CRC) was investigated in several lines, the expression and function of DAAM in CRC are still obscure.

objectiveTo investigate the expression and function of DAAM in CRC.

methodsDAAM1 and DAAM2 expression in high grade dysplasia (HGD), CRCs and corresponding adjacent tissues were detected with qRT-PCR and immunohistochemistry (IHC). The prognostic significance of DAAM1/2 were estimated with univariate and multivariate analyses. Moreover, the correlations between clinicopathological factors and DAAM were evaluated with the χ

resultsDAAM2, instead of DAAM1, was substantially up-regulated in CRCs compared with paired adjacent normal tissues and HGDs. The ratio of high DAAM1 and DAAM2 expression accounted for 44.83% and 46.31%, respectively. High DAAM2, instead of DAAM1, was a risk factor indicating an unfavorable prognosis of CRC. In multivariate analysis, high DAAM2 was identified as an independent prognostic biomarker of CRC predicting poor prognosis. With experiments in vitro, DAAM2 promoted invasion of CRC cells via activating PAK1 and promoting the expression of MMP7, suggesting an essential role of DAAM2 in CRC invasion.

conclusionsHigh expression of DAAM2, instead of DAAM1, indicated an unfavorable prognosis of CRC independently, which suggested that detecting DAAM2 can help define the high-risk patients. DAAM2 activated PAK1 and promoted MMP7 expression and facilitated the invasion of CRC cells, indicating that DAAM2 may be a potential drug target of CRC.

Indexed as

AdultAgedCell Line, TumorCell MovementCell ProliferationColorectal NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansMaleMatrix Metalloproteinase 7Microfilament ProteinsMiddle AgedNeoplasm Invasivenessp21-Activated Kinasesrho GTP-Binding ProteinsDAAM1 protein, humanDAAM2 protein, humanMatrix Metalloproteinase 7Microfilament Proteinsp21-Activated KinasesPAK1 protein, humanrho GTP-Binding ProteinsColorectal cancerDisheveled-associated activator of morphogenesis 2InvasionPAK1Prognosis

Identifiers

PMID33974241
OpenAlexW3160408730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.