SynthesisEuropean radiology2021
Predictors of failed enema reduction in children with intussusception: a systematic review and meta-analysis.
Synthesis in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Effectiveness of ultrasound-guided hydrostatic versus fluoroscopy-guided air reduction for pediatric intussusception: a severity-adjusted cohort analysis.Pediatric surgery international · 2026Article
- Biomarker-Based Prediction of Treatment Outcomes in Pediatric Intussusception: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Failed ultrasound-guided hydrostatic reduction in pediatric intussusception: surgical-pathological characterization of failure phenotypes under a standardized protocol.Pediatric surgery international · 2026Article
- Fluoroscopic image-driven deep learning model for predicting intussusception irreducibility during air enema in children.BMC medical imaging · 2026Article
- Determinants of ultrasound-guided reduction failure and pathological lead points in pediatric intussusception.Pediatric surgery international · 2026Article
- Systemic immune inflammatory index (SII) as a predictive marker for the failure of air enema treatment in children with Ileocolic intussusception: a case-control study.BMC pediatrics · 2025Article
- Clinical Determinants of Unsuccessful Ultrasound-Guided Hydrostatic Saline Reduction in Children with Intussusception Post-Rotavirus Vaccine Introduction: Insights from a Tertiary Care Centre in Thrissur, Kerala, India.Indian journal of pediatrics · 2025Observational
- Clinical, imaging and surgical outcomes of secondary intussusceptions in children: a retrospective analysis based on the benign and malignant pathologic lead points.Translational pediatrics · 2025Article
- Ultrasound-guided hydrostatic enema reduction for recurrent intussusception in children: a retrospective analysis of 215 cases.Pediatric surgery international · 2025Article
- Opioid Administration and Reduction of Pediatric Ileocolic Intussusception.JAMA network open · 2025Article
- Article
- Photoacoustic oxygenation imaging to identify ischemia/hypoxia injury and necrosis of intestine after acute intussusception: A comparative study with CDFI/CEUS.Photoacoustics · 2025Article
- Is sedation necessary for hydrostatic reduction in ileocolic intussusception? Evaluating procedural outcomes and parents' preferences.World journal of pediatric surgery · 2025Article
- Comparison of success rates in intussusception reduction in children: colonoscopy versus ultrasound-guided saline enema.Gastroenterology and hepatology from bed to bench · 2025Article
- Risk factors associated with the outcomes of fluoroscopy guided pneumatic enema reductions of intussusceptions.SA journal of radiology · 2025Article
- Nomogram for spontaneous reduction in pediatric intussusception: a retrospective study.Frontiers in pediatrics · 2025Article
- Practice variation in the management of pediatric intussusception: a narrative review.European journal of pediatrics · 2024Review
- Developing a nomogram to predict recurrent intussusception after pneumatic reduction of primary intussusception in children.BMC surgery · 2024Article
- Risk factors for failure of enema reduction of intussusception in children.Scientific reports · 2024Article
- Impact of a 6-12-h delay between ileocolic intussusception diagnostic US and fluoroscopic reduction on patients' outcomes.Pediatric radiology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo identify predictors of failed enema reduction in children with intussusception.
methodsPubMed and EMBASE were searched for all studies published over a 20-year time frame, prior to March 25, 2020. Original articles that reported predictors of failed enema reduction were included. The pooled odds ratio (OR) for successful enema reduction according to various features was calculated. The combined estimates were meta-analytically pooled by random-effects modeling. The risk of bias was assessed using the National Institute of Health Quality Assessment Tool. This review was registered to the PROSPERO (CRD42020190178).
resultsA total of 38 studies, comprising 40,133 cases, were included. The shorter duration of symptoms (< 24 h; combined OR, 3.812; 95% CI, 2.150-6.759) and abdominal pain (combined OR, 2.098; 95% CI, 1.405-3.133) were associated with the success (all p < 0.001). Age < 1 year (combined OR, 0.385; 95% CI, 0.166-0.893; p = 0.026), fever (combined OR, 0.519; 95% CI, 0.371-0.725; p < 0.001), rectal bleeding (combined OR, 0.252; 95% CI, 0.165-0.387; p < 0.001), and vomiting (combined OR, 0.497; 95% CI, 0.372-0.664; p < 0.001) were associated with the failed reduction. The ascites (combined OR, 0.127; 95% CI, 0.044-0.368; p = 0.001), left-sided intussusception (combined OR, 0.121; 95% CI, 0.058-0.252; p < 0.001), and trapped fluid (combined OR, 0.179; 95% CI, 0.061-0.525; p = 0.017) on US were associated with the failed reduction.
conclusionsSuccessful predictors for intussusception reduction have been summarized. This evidence can help identify patients who are more likely to fail non-operative reduction and could be potential surgical candidates. KEY POINTS: • A shorter duration of symptoms and presence of abdominal pain were associated with increased probability of success. • Age (less than 1 year), presence of fever, rectal bleeding, vomiting, and presence of ascites, left-sided intussusception, or trapped fluid on ultrasonography were associated with decreased probability of success. • This study suggests that various clinical and ultrasonography predictors would help identify patients who are more likely to fail nonoperative reduction and identify potential preoperative candidates.
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