Evidence map›Paper›PMID 33974122›Full record

ArticleMedical microbiology and immunology2021

The role of HIF-1α in BCG-stimulated macrophages polarization and their tumoricidal effects in vitro.

Pei Zhu, Yuyang Hou, Mengyan Tang, Zheng Jin, Youran Yu, Dong Li, Dongmei Yan, Zehua Dong

Abstract read
PubMed Publisher
In one paragraph

Article in Medical microbiology and immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pei ZhuDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.ORCID http://orcid.org/0000-0001-9257-5394
Yuyang HouDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Mengyan TangDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Zheng JinDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Youran YuShanghai University of Medicine and Health Sciences, Shanghai, China.
Dong LiDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Dongmei YanDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China. dmyan@jlu.edu.cn.
Zehua DongDepartment of critical care medicine, The Affiliated Hospital of Qingdao University, Qingdao, China. dongzehuazp@163.com.
Jilin University · CNQingdao University · CNShanghai University of Medicine and Health Sciences · CN

Funding

Education Department of Jilin Province JJKH20190095KJNational Natural Science Foundation of China 81871245
6 · The paper itself

Abstract

BCG is widely used for cancer treatment, where macrophages play an important role. However, the mechanism of BCG affecting macrophages remains poorly understood. In this study, we used BCG to stimulate myeloid-derived macrophages lacking HIF-1α, the levels of TNF-α, IL-1β, CD86 of macrophages and their effects on the growth of tumor cells MCA207 and B16-F10 were detected. We found that the absence of HIF-1α prevents BCG-stimulated macrophages from polarizing towards the M (BCG) and attenuating its killing effect on tumor cells. In addition, we demonstrated that the tumors of mice lacking HIF-1α in macrophages were significantly increased by the experiment of mice transplantation. Our study provides relevant evidence for exploring the mechanism of the BCG vaccine in the prevention and treatment of related diseases.

Indexed as

Macrophage ActivationAnimalsAntineoplastic AgentsB7-2 AntigenBCG VaccineCell Line, TumorCytokinesHypoxia-Inducible Factor 1, alpha SubunitInterleukin-1betaMacrophagesMiceMice, KnockoutModels, AnimalNeoplasmsNeoplasm TransplantationTumor Necrosis Factor-alphaAntineoplastic AgentsB7-2 AntigenBCG VaccineCytokinesHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitIL1B protein, mouseInterleukin-1betaTumor Necrosis Factor-alphaBCGHIF-1αMacrophagesPolarizedTumor

Identifiers

PMID33974122
OpenAlexW3161038472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.