Evidence map›Paper›PMID 33973871›Full record

ArticleAging2021

CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis.

Lei Yi, Kai Ai, Huiling Li, Shuangfa Qiu, Yijian Li, Yinhuai Wang, Xiaozhou Li, Peilin Zheng, Junxiang Chen, Dengke Wu and 4 more

Abstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lei YiDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Kai AiDepartment of Urology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Huiling LiDepartment of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Shuangfa QiuDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yijian LiDepartment of Urology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yinhuai WangDepartment of Urology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xiaozhou LiDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Peilin ZhengDepartment of Endocrinology, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, People's Republic of China.
Junxiang ChenDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Dengke WuDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xudong XiangDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xiangping ChaiDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yunchang YuanDepartment of Chest Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Dongshan ZhangDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated the role of circular RNA_30032 (circRNA_30032) in renal fibrosis and the underlying mechanisms. The study was carried out using TGF-β1-induced BUMPT cells and unilateral ureteral obstruction (UUO)-induced mice, respectively, as

Indexed as

AnimalsCell LineDisease Models, AnimalEpithelial CellsFibrosisGene Expression RegulationGene Knockdown TechniquesHeparin-binding EGF-like Growth FactorHumansKidneyMaleMAP Kinase Signaling SystemMiceMicroRNAsp38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins p21(ras)Hbegf protein, mouseHeparin-binding EGF-like Growth FactorHras protein, mouseMicroRNAsMirn96 microRNA, mousep38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins p21(ras)RNA, CircularTgfb1 protein, mouseTransforming Growth Factor beta1circRNA_30032HBEGFKRASmiR-96-5pUUO

Identifiers

PMID33973871
PMCPMC8148471

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.