Evidence map›Paper›PMID 33973523›Full record

ArticleeLife2021

A developmental framework linking neurogenesis and circuit formation in the

Brandon Mark, Sen-Lin Lai, Aref Arzan Zarin, Laurina Manning, Heather Q Pollington, Ashok Litwin-Kumar, Albert Cardona, James W Truman, Chris Q Doe

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
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  5. Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026
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  15. Synaptic architecture of leg and wing premotor control networks inbioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Brandon MarkInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.
Sen-Lin LaiInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.ORCID 0000-0002-7531-283X
Aref Arzan ZarinInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.ORCID 0000-0003-0484-3622
Laurina ManningInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.
Heather Q PollingtonInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.
Ashok Litwin-KumarMortimer B Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, United States.ORCID 0000-0003-2422-6576
Albert CardonaJanelia Research Campus, Howard Hughes Medical Institute, MRC Laboratory of Molecular Biology, Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-4941-6536
James W TrumanJanelia Research Campus, Howard Hughes Medical Institute, Friday Harbor Laboratories, University of Washington, Friday Harbor, United States.ORCID 0000-0002-9209-5435
Chris Q DoeInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.ORCID 0000-0001-5980-8029
Howard Hughes Medical Institute · USColumbia University · USMRC Laboratory of Molecular Biology · GB

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Graduate Training in Genetics Administrative Supplement - Career Curriculum DevelopmentT32GM007413 · NIGMS · UNIVERSITY OF OREGON · PI GUILLEMIN, KAREN J · 1985 to 2022
$7.8M
DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007348 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe, KRYN STANKUNAS · 1989 to 2026
$6.8M
GENETIC AND MOLECULAR STUDIES OF NEUROGENESISR01HD027056 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe · 1989 to 2026
$5.0M
Genetic and Molecular Studies of NeurogenesisR37HD027056 · NICHD · UNIVERSITY OF OREGON · PI DOE, CHRIS Q · 2012 to 2021
$3.0M
Relating structure and function in synapse-level wiring diagramsR01EB029858 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LITWIN-KUMAR, ASHOK · 2020 to 2020
$1.2M
Howard Hughes Medical InstituteMedical Research Council MC_UP_1201/21NIBIB NIH HHS R01 EB029858NICHD NIH HHS R01 HD027056NICHD NIH HHS R37 HD027056NICHD NIH HHS T32 HD007348NIGMS NIH HHS T32 GM007413NIH HHS P40 OD018537
6 · The paper itself

Abstract

The mechanisms specifying neuronal diversity are well characterized, yet it remains unclear how or if these mechanisms regulate neural circuit assembly. To address this, we mapped the developmental origin of 160 interneurons from seven bilateral neural progenitors (neuroblasts) and identify them in a synapse-scale TEM reconstruction of the

Indexed as

AnimalsCentral Nervous SystemDrosophila melanogasterDrosophila ProteinsNeural Stem CellsNeurogenesisDrosophila Proteinscell lineagedevelopmental biologyD. melanogasterhemilineageneural circuitneuroblastneuroscienceNotchtemporal identity

Identifiers

PMID33973523
PMCPMC8139831
OpenAlexW3160988473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.