Evidence map›Paper›PMID 33973501›Full record

ArticlePrehospital and disaster medicine2021

A Comparison of Time to Treatment between an Emergency Department Focused Stroke Protocol and Mobile Stroke Units.

Debbie Y Madhok, Paul H Mangasarian, Kevin J Keenan, J Claude Hemphill, John F Brown, Anthony S Kim

Open access · greenAbstract read
In one paragraph

Article in Prehospital and disaster medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Debbie Y MadhokDepartment of Emergency Medicine, University of California San Francisco, San Francisco, CaliforniaUSA.ORCID https://orcid.org/0000-0003-0694-9690
Paul H MangasarianSchool of Medicine, University of California Davis, Sacramento, CaliforniaUSA.
Kevin J KeenanDepartment of Neurology, University of California Davis, Sacramento, CaliforniaUSA.
J Claude HemphillDepartment of Neurology, University of California San Francisco, San Francisco, CaliforniaUSA.
John F BrownDepartment of Emergency Medicine, University of California San Francisco, San Francisco, CaliforniaUSA.
Anthony S KimDepartment of Neurology, University of California San Francisco, San Francisco, CaliforniaUSA.
University of California, San Francisco · USUniversity of California, Davis · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Smith_U24_Supplement P0570485 5 30 2023U24NS107229 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anthony Suyoung Kim · 2018 to 2026
$2.9M
NorCal - Coordinating Stroke CenterU10NS086494 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SMITH, WADE S · 2013 to 2017
$2.0M
NCATS NIH HHS UL1 TR001860NINDS NIH HHS U10 NS086494NINDS NIH HHS U24 NS107229
6 · The paper itself

Abstract

backgroundSan Francisco (California USA) is a relatively compact city with a population of 884,000 and nine stroke centers within a 47 square mile area. Emergency Medical Services (EMS) transport distances and times are short and there are currently no Mobile Stroke Units (MSUs).

methodsThis study evaluated EMS activation to computed tomography (CT [EMS-CT]) and EMS activation to thrombolysis (EMS-TPA) times for acute stroke in the first two years after implementation of an emergency department (ED) focused, direct EMS-to-CT protocol entitled "Mission Protocol" (MP) at a safety net hospital in San Francisco and compared performance to published reports from MSUs. The EMS times were abstracted from ambulance records. Geometric means were calculated for MP data and pooled means were similarly calculated from published MSU data.

resultsFrom July 2017 through June 2019, a total of 423 patients with suspected stroke were evaluated under the MP, and 166 of these patients were either ultimately diagnosed with ischemic stroke or were treated as a stroke but later diagnosed as a stroke mimic. The EMS and treatment time data were available for 134 of these patients with 61 patients (45.5%) receiving thrombolysis, with mean EMS-CT and EMS-TPA times of 41 minutes (95% CI, 39-43) and 63 minutes (95% CI, 57-70), respectively. The pooled estimates for MSUs suggested a mean EMS-CT time of 35 minutes (95% CI, 27-45) and a mean EMS-TPA time of 48 minutes (95% CI, 39-60). The MSUs achieved faster EMS-CT and EMS-TPA times (P <.0001 for each).

conclusionsIn a moderate-sized, urban setting with high population density, MP was able to achieve EMS activation to treatment times for stroke thrombolysis that were approximately 15 minutes slower than the published performance of MSUs.

Indexed as

Emergency Medical ServicesStrokeAmbulancesEmergency Service, HospitalHumansTime-to-TreatmentEmergency Medical Servicesischemic strokemobile stroke unitstroke

Identifiers

PMID33973501
PMCPMC12109711
OpenAlexW3163299237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.