ArticleArthritis care & research2022
Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.
Article in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Factors Associated with Chronic Low Back Pain in Hungary Based on the European Health Interview Surveys Conducted in 2009, 2014, and 2019: A Repeated Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Development and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion.Journal of orthopaedic surgery and research · 2025Article
- Transition from acute to chronic low back pain in a community-based cohort.The journal of pain · 2025Article
- Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Classification of Osteophytes Occurring in the Lumbar Intervertebral Foramen.Tomography (Ann Arbor, Mich.) · 2024Article
- The relationship between structural changes in paraspinal muscles and intervertebral disc and facet joint degeneration in the lumbar spine of rats.Journal of orthopaedic surgery and research · 2024Article
- Characterizing Acute Low Back Pain in a Community-Based Cohort: Results from a Feasibility Cohort Study.Journal of pain research · 2024Article
- Examining the influence of body fat distribution on standing balance and functional performance in overweight female patients with degenerative lumbar disease.Frontiers in bioengineering and biotechnology · 2024Article
- Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project.Osteoarthritis and cartilage · 2023Article
- Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: The Johnston County Osteoarthritis Project.Osteoarthritis and cartilage open · 2022Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the incidence and worsening of lumbar spine structure and low back pain (LBP) and whether they are predicted by demographic characteristics or clinical characteristics or appendicular joint osteoarthritis (OA).
methodsPaired baseline (2003-2004) and follow-up (2006-2010) lumbar spine radiographs from the Johnston County Osteoarthritis Project were graded for osteophytes (OST), disc space narrowing (DSN), spondylolisthesis, and presence of facet joint OA (FOA). Spine OA was defined as at least mild OST and mild DSN at the same level for any level of the lumbar spine. LBP, comorbidities, and back injury were self-reported. Weibull models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) of spine phenotypes accounting for potential predictors including demographic characteristics, clinical characteristics, comorbidities, obesity, and appendicular OA.
resultsObesity was a consistent and strong predictor of incidence of DSN (HR 1.80 [95% CI 1.09-2.98]), spine OA (HR 1.56 [95% CI 1.01-2.41]), FOA (HR 4.99 [95% CI 1.46-17.10]), spondylolisthesis (HR 1.87 [95% CI 1.02-3.43]), and LBP (HR 1.75 [95% CI 1.19-2.56]), and worsening of DSN (HR 1.51 [95% CI 1.09-2.09]) and LBP (HR 1.51 [95% CI 1.12-2.06]). Knee OA was a predictor of incident FOA (HR 4.18 [95% CI 1.44-12.2]). Spine OA (HR 1.80 [95% CI 1.24-2.63]) and OST (HR 1.85 [95% CI 1.02-3.36]) were predictors of incidence of LBP. Hip OA (HR 1.39 [95% CI 1.04-1.85]) and OST (HR 1.58 [95% CI 1.00-2.49]) were predictors of LBP worsening.
conclusionAmong the multiple predictors of spine phenotypes, obesity was a common predictor for both incidence and worsening of lumbar spine degeneration and LBP.
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