Evidence map›Paper›PMID 33973379›Full record

SynthesisInternational journal of rheumatic diseases2021

Recommendations for COVID-19 vaccination in people with rheumatic disease: Developed by the Singapore Chapter of Rheumatologists.

Amelia Santosa, Chuanhui Xu, Thaschawee Arkachaisri, Kok Ooi Kong, Aisha Lateef, Tau Hong Lee, Keng Hong Leong, Andrea Hsiu Ling Low, Melonie K Sriranganathan, Teck Choon Tan and 4 more

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in International journal of rheumatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  11. Covid-19 vaccination among people with disability-Statement from the iADH scientific committee.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Amelia SantosaDivision of Rheumatology, Department of Medicine, National University Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0003-2973-0798
Chuanhui XuDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0002-3222-7168
Thaschawee ArkachaisriRheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0002-1387-1169
Kok Ooi KongDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0003-2635-4715
Aisha LateefDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID https://orcid.org/0000-0002-0838-7495
Tau Hong LeeNational Centre for Infectious Diseases, Singapore, Singapore.
Keng Hong LeongLeong Keng Hong Arthritis and Medical Clinic, Singapore, Singapore.
Andrea Hsiu Ling LowDepartment of Rheumatology & Immunology, Singapore General Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0002-5244-686X
Melonie K SriranganathanDepartment of Medicine, Changi General Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0002-5551-9112
Teck Choon TanDivision of Rheumatology, Department of Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0001-6566-050X
Gim Gee TengDivision of Rheumatology, Department of Medicine, National University Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0002-1128-5780
Bernard Yu-Hor ThongDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0002-6338-8482
Warren FongDepartment of Rheumatology & Immunology, Singapore General Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0003-1891-1892
Manjari LahiriDivision of Rheumatology, Department of Medicine, National University Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0002-3482-6017
National University of Singapore · SGTan Tock Seng Hospital · SGSingapore General Hospital · SGChangi General Hospital · SGInstitute of Medical Biology · SGKhoo Teck Puat Hospital · SGKK Women's and Children's Hospital · SGNational Centre for Infectious Diseases · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPeople with rheumatic diseases (PRD) remain vulnerable in the era of the COVID-19 pandemic. We formulated recommendations to meet the urgent need for a consensus for vaccination against SARS-CoV-2 in PRD.

methodsSystematic literature reviews were performed to evaluate: (a) outcomes in PRD with COVID-19; (b) efficacy, immunogenicity and safety of COVID-19 vaccination; and (c) published guidelines/recommendations for non-live, non-COVID-19 vaccinations in PRD. Recommendations were formulated based on the evidence and expert opinion according to the Grading of Recommendations Assessment, Development and Evaluation methodology.

resultsThe consensus comprises 2 overarching principles and 7 recommendations. Vaccination against SARS-CoV-2 in PRD should be aligned with prevailing national policy and should be individualized through shared decision between the healthcare provider and patient. We strongly recommend that eligible PRD and household contacts be vaccinated against SARS-CoV-2. We conditionally recommended that the COVID-19 vaccine be administered during quiescent disease if possible. Immunomodulatory drugs, other than rituximab, can be continued alongside vaccination. We conditionally recommend that the COVID-19 vaccine be administered prior to commencing rituximab if possible. For patients on rituximab, the vaccine should be administered a minimum of 6 months after the last dose and/or 4 weeks prior to the next dose of rituximab. Post-vaccination antibody titers against SARS-CoV-2 need not be measured. Any of the approved COVID-19 vaccines may be used, with no particular preference.

conclusionThese recommendations provide guidance for COVID-19 vaccination in PRD. Most recommendations in this consensus are conditional, reflecting a lack of evidence or low-level evidence.

Indexed as

Practice Guidelines as TopicRheumatologistsCOVID-19COVID-19 VaccinesHumansPandemicsRheumatic DiseasesSARS-CoV-2SingaporeVaccinationCOVID-19 VaccinesCOVID-19immunosuppressionpeople with rheumatic diseasesSARS-CoV-2vaccination

Identifiers

PMID33973379
PMCPMC8207070
OpenAlexW3160026234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.