Evidence map›Paper›PMID 33973197›Full record

ReviewAdvances in experimental medicine and biology2021

Dietary Supplements for COVID-19.

Gerard E Mullin, Berkeley Limektkai, Lin Wang, Patrick Hanaway, Loren Marks, Edward Giovannucci

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. COVID-19 Pandemic and Consumption of Dietary Supplements among Adult Residents of Lithuania.International journal of environmental research and public health · 2022
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Gerard E MullinThe Johns Hopkins School of Medicine, Baltimore, MD, USA. gmullin1@jhmi.edu.
Berkeley LimektkaiThe University of California Los Angeles School of Medicine, Los Angeles, CA, USA.
Lin WangThe Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Patrick HanawayCleveland Clinic Center for Functional Medicine, Cleveland, OH, USA.
Loren MarksIntegrative Nutrition, New York, NY, USA.
Edward GiovannucciThe Harvard TH Chan School of Public Health, Boston, MA, USA.
Johns Hopkins University · USCleveland Clinic · USHarvard University · USIntegrative Medicine Institute · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease that can rapidly escalate to respiratory failure and death. It has infected millions of people worldwide. The trajectory of this disease continues to progress in some areas of the United States and worldwide. The Institute for Health Metrics now predicts a resurgence of infections in the fall of 2020. The pathogenesis of COVID-19 includes an inflammatory phase with either resolution or the potential to accelerate to a cytokine storm, characterized by high interleukin (IL)-6 and other inflammatory markers. COVID-19 is a condition without a gold-standard treatment. The US Federal Drug Administration (FDA) issued an emergency use authorization for remdesivir in severe cases of COVID-19, which shortened the recovery time in hospitalized patients with lower respiratory tract infection in one study. Although several vaccine trials are underway, no vaccines are available for primary prevention of COVID-19 at this time. Dietary supplement sales have dramatically risen during the COVID-19 pandemic despite depressed economic conditions. Commonly used immune-modulating dietary supplements, including vitamin D, ascorbic acid, zinc, and melatonin, are reviewed in this manuscript highlighting biological plausibility for salutary benefit against COVID-19. Ongoing clinical trials recruiting subjects at the time of this writing are provided for each dietary supplement.

Indexed as

COVID-19Dietary SupplementsPandemicsHumansSARS-CoV-2United StatesVitamin DVitamin DCOVID-19Cytokine stormInflammasomeMelatoninSARS-CoV-2Vitamin CVitamin DZinc

Identifiers

PMID33973197
OpenAlexW3162340139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.