Evidence map›Paper›PMID 33973178›Full record

ArticleAdvances in experimental medicine and biology2021

COVID-19 and Cell Stress.

Abdo A Elfiky, Ibrahim M Ibrahim, Fatma G Amin, Alaa M Ismail, Wael M Elshemey

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Abdo A ElfikyBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt. abdo@sci.cu.edu.eg.
Ibrahim M IbrahimBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Fatma G AminPhysics Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Alaa M IsmailBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Wael M ElshemeyBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Cairo University · EGAlexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present century will undoubtedly be marked with the COVID-19 global health crisis. It is not time yet to talk about the total number of deaths and hospitalizations, as they are enormously growing daily. Understanding the nature of COVID-19-induced pneumonia is vital in order to deal with the associated health complications. Cell stress is an established mechanism known to be associated with infection and cancer. Different proteins crucial for cellular response to stress are reported to be a possible target to stop the infection and to reduce the chemo-resistance in cancer. Heat shock protein (HSP) families of chaperones play an essential role in cells both in normal state and under stress. The upregulation of HSP5A, also termed GRP78 or Bip, is reported in different viral infections. This chapter introduces the current knowledge about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has caused the COVID-19 pandemic, and cell stress aimed at defining possible strategies to combat the COVID-19 pandemic.

Indexed as

Cell Physiological PhenomenaCOVID-19NeoplasmsStress, PhysiologicalEndoplasmic Reticulum Chaperone BiPGlobal HealthHumansPandemicsSARS-CoV-2Endoplasmic Reticulum Chaperone BiPHSPA5 protein, humanCell stressChaperoneCOVID-19GRP78SARS-CoV-2Spike

Identifiers

PMID33973178
OpenAlexW3162355583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.