ReviewCurrent pain and headache reports2021
Mechanism of Action of Peripheral Nerve Stimulation.
Review in Current pain and headache reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05971095 (Percutaneous Femoral Nerve Neuromodulation for Postoperative Analgesia and Functional Recovery Following Knee Arthroplasty.), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Percutaneous Femoral Nerve Neuromodulation for Postoperative Analgesia and Functional Recovery Following Knee Arthroplasty.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Narrative reviews in anesthesia and pain medicine: guidelines for producers, reviewers and consumers.Regional anesthesia and pain medicine · 2025Guideline
- Peripheral nerve stimulation for chronic knee pain following total knee arthroplasty: a systematic review.Pain management · 2023Pooled it
- Peripheral Nerve Stimulation for Low Back Pain: A Systematic Review.Current pain and headache reports · 2023Pooled it
- Neuromodulation Interventions for the Treatment of Painful Diabetic Neuropathy: a Systematic Review.Current pain and headache reports · 2022Pooled it
- Neuromodulation Techniques Alleviating Neuropathic Pain by Targeting Microglia: A Narrative Review.Pain and therapy · 2026Review
- An injectable, leadless bioelectronic interface for battery-free wireless peripheral neuromodulation.Science advances · 2026Article
- Not who we treat, but how we treat: Emphasizing treatment adherence in neuromodulation outcomes.Interventional pain medicine · 2026Article
- Peripheral nerve stimulation targeting the trochanteric branch of the femoral nerve for refractory greater trochanteric pain syndrome followed by dorsal root ganglion stimulation: A case report and mechanistic perspective.Interventional pain medicine · 2026Article
- Pain intensity and opioid consumption after temporary and permanent peripheral nerve stimulation: a 2-year multicenter analysis.Regional anesthesia and pain medicine · 2025Article
- Temporary Peripheral Nerve Stimulation (PNS) of the Cervical Medial Branch Nerve (CMBN) for Chronic Axial Neck Pain-A Literature Review and Case Series.Journal of clinical medicine · 2025Review
- Patient-Reported Outcomes with Peripheral Nerve Stimulation for Low Back Pain from Vertebral Plana Deformities: A Case Series.Journal of clinical medicine · 2025Article
- A novel single-lead percutaneous approach for multi-nerve peripheral stimulation in upper extremity pain: A case report.Interventional pain medicine · 2025Article
- Allergic reaction to temporary percutaneous peripheral stimulation leads: A case report.Interventional pain medicine · 2025Article
- Repetitive Transcranial Magnetic Stimulation for the Treatment of Spinal Cord Injury: Current Status and Perspective.International journal of molecular sciences · 2025Review
- Neuromodulation guide for the non-neuromodulator clinician: What it is and how it can benefit patients?Biomolecules & biomedicine · 2025Review
- Real-world long-term outcomes of peripheral nerve stimulation: a prospective observational study.Pain management · 2025Observational
- Article
- Latest Advances in Regional Anaesthesia.Medicina (Kaunas, Lithuania) · 2024Review
- Retrospective Evaluation of Bipolar Peripheral Nerve Stimulation for Nociceptive and Neuropathic Pain: A Pilot Study.Journal of pain research · 2024Article
- Pathophysiology of Pain and Mechanisms of Neuromodulation: A Narrative Review (A Neuron Project).Journal of pain research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe number of applications for peripheral nerve stimulation (PNS) in the pain management field is ever-growing. With the increasing number of clinical applications for peripheral nerve stimulation, the purpose of this article is to review the mechanism of action surrounding PNS, the recent literature from January 2018 to January 2021, and pertinent clinical outcomes. RECENT
findingsThe authors searched articles identified from PubMed (January 2018-January 2021), Cochrane Central Register of Controlled Trials databases (January 2018-January 2021), and Scopus (January 2018-January 2021) databases, and manually searched references of identified publications. Broad MeSH terms and Boolean operators were queried in each search, including the following terms and their respective synonyms: peripheral nerve stimulation, mechanism of action, biochemical pathway, and pain pathway. 15 consensus articles were selected for in-depth review and inclusion for qualitative analysis. PNS may activate and modulate higher central nervous system (CNS) centers, including the dorsal lateral prefrontal cortex, somatosensory cortex, anterior cingulate cortex, and parahippocampal areas. Neuromodulatory effects from PNS may also extend into the spinal columns. Also, PNS may lead to changes in endogenous neurotransmitters and affect the plasticity of NMDA pathways.
Indexed as
Identifiers
33973135What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.