ArticleAnnals of biomedical engineering2021
In Silico Clinical Trials in the Orthopedic Device Industry: From Fantasy to Reality?
Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Rapid personalized computational modeling of the wrist.Medical engineering & physics · 2026Article
- Fractures Around Collared and Collarless Hip Stems Initiate in High Strain Regions: A Combined Cadaveric Experiment and Finite Element Analysis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Digital twins for the era of personalized surgery.NPJ digital medicine · 2025Review
- Credibility assessment of in silico clinical trials for medical devices.PLoS computational biology · 2024Review
- Developing and Validating a Model of Humeral Stem Primary Stability, Intended for In Silico Clinical Trials.Annals of biomedical engineering · 2024Article
- Impact of mechanical engineering innovations in biomedical advancements.In vitro models · 2024Review
- Toward trustworthy medical deviceFrontiers in medicine · 2024Article
- Innovative technologies for reverse total shoulder arthroplasty in Australia: Market access challenges and implications for patients, decision-makers, and manufacturers.Journal of market access & health policy · 2023Review
- Mapping the use of computational modelling and simulation in clinics: A survey.Frontiers in medical technology · 2023Article
- An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone.BMC biomedical engineering · 2022Article
- Special Issue of the VPH2020 Conference: "Virtual Physiological Human: When Models, Methods and Experiments Meet the Clinic".Annals of biomedical engineering · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The orthopedic device industry relies heavily on clinical evaluation to confirm the safety, performance, and clinical benefits of its implants. Limited sample size often prevents these studies from capturing the full spectrum of patient variability and real-life implant use. The device industry is accustomed to simulating benchtop tests with numerical methods and recent developments now enable virtual "in silico clinical trials" (ISCT). In this article, we describe how the advancement of computer modeling has naturally led to ISCT; outline the potential benefits of ISCT to patients, healthcare systems, manufacturers, and regulators; and identify how hurdles associated with ISCT may be overcome. In particular, we highlight a process for defining the relevant patient risks to address with ISCT, the utility of a versatile software pipeline, the necessity to ensure model credibility, and the goal of limiting regulatory uncertainty. By complementing-not replacing-traditional clinical trials with computational evidence, ISCT provides a viable technical and regulatory strategy for characterizing the full spectrum of patients, clinical conditions, and configurations that are embodied in contemporary orthopedic implant systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.