ArticleJournal of neurology2021
Thalamic versus midbrain tremor; two distinct types of Holmes' Tremor: a review of 17 cases.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Movement Disorders in Neurocysticercosis: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Pooled it
- Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor.Seminars in neurology · 2026Review
- The heterogeneity of thalamic tremor: report of two cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Holmes Tremor Following Thalamic Tuberculoma-A Case Report and Literature Review.Clinical case reports · 2026Article
- Holmes Tremor Secondary to a Brainstem Haemorrhage With Partial Symptomatic Improvement Following Levetiracetam Use.Cureus · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Expanding the Clinical Spectrum of Head Snap Sign.Movement disorders clinical practice · 2026Article
- Holmes Tremor in CADASIL Responsive to Multi-Targeting Deep Brain Stimulation (DBS): An Educational Case with Video and Electrophysiology.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Holmes tremor following midbrain hemorrhage - An illustrative case.Surgical neurology international · 2025Article
- Bedside clinical assessment of patients with common upper limb tremor and algorithmic approach.Asian biomedicine : research, reviews and news · 2024Review
- Analysis of Semiology, Lesion Topography and Treatment Outcomes: A Prospective Study on Post Thalamic Stroke Holmes Tremor.Journal of movement disorders · 2024Article
- Post-stroke Everything.Current neurology and neuroscience reports · 2023Review
- Clinical Features, Neuroimaging, and Levodopa-Responsiveness in Holmes' Tremor: A Video-Based Case-Series with a Review of the Literature.Movement disorders clinical practice · 2022Review
- Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Review
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHolmes Tremor (HT) is a unique and debilitating movement disorder. It usually results from lesions of the midbrain and its connection but can also result from posterior thalamic injury. Clinical examination can help lesion localization between these two areas. We studied the clinical features and their radiological correlations to distinguish midbrain HT (HT-m) from thalamic HT (HT-t).
methodsRetrospective review of 17 patients with a HT-type presentation was conducted. Tremor characteristics, associated clinical signs and radiological findings were studied.
resultsEleven patients had a myorythmic rest tremor, large amplitude proximal tremor with goal-directed worsening, with or without mild distal dystonic posturing, representing HT-m. Six patients had slow, large amplitude proximal tremors and distal choreathetoid movements, significant proximal/distal dystonic posturing, associated with proprioceptive sensory loss, representing HT-t. Haemorrhagic lesions were the predominant cause of HT-m; whereas, ischaemia was more commonly associated with HT-t.
conclusionWhen assessing patients with HT, attentiveness to the presence of associated signs in the affected limb, such as a proprioceptive sensory deficits and additional movement disorders, can aid lesion localisation, which can have implications for management.
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Registered trials
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