ArticleChemical Society reviews2021
Recent advances in the chemistry of ketyl radicals.
Article in Chemical Society reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Total Synthesis of Schisanlactone A and Ganodermalactone H via Selective Transformation of a Cycloheptatriene Intermediate.JACS Au · 2026Article
- Intermolecular Reductive Coupling of Ketones and Alkenes under Ferrioxalate Photocatalysis.Journal of the American Chemical Society · 2026Article
- Efficient and scalable photochemical coupling of pinacol and aza-pinacol in continuous-flow.Communications chemistry · 2026Article
- Redox-neutral ketone-olefin coupling enabled by mild ketone-to-ketyl-type radical conversion.Nature chemistry · 2026Article
- Ketones to ketyls by radical relocation.Nature chemistry · 2026Article
- Isolation and reactivity of an alkyl-substituted germanium(I) radical anion.Nature communications · 2026Article
- Aldehyde-Olefin Couplings by Photoinduced Reduction of Electron-Deficient Olefins with Hantzsch Ester Anions.Angewandte Chemie (International ed. in English) · 2026Article
- Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Generation of a Ground-State Electron Donor Utilizing Stored Light Energy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Concise synthesis of bufogargarizin B by a conformation-controlled skeletal reorganization approach.Nature communications · 2026Article
- Methyl Viologen Lead Iodide for Photocatalytic Reductive Coupling of Aromatic Carbonyls via Proton-Coupled Electron Transfer.ACS applied materials & interfaces · 2026Article
- Ga-Based Liquid Metal Catalyst for Mechano-Assisted Carbon-Carbon Coupling Reaction.Research (Washington, D.C.) · 2026Article
- Virtual Ligand-Assisted Screening for the Generation of Ketyl Radicals from Alkyl Ketones via Photoexcited Palladium Catalysis.Journal of the American Chemical Society · 2025Article
- SmIAngewandte Chemie (International ed. in English) · 2025Article
- Radical C─H-Aroylation of Allenes via Cooperative Photoredox and N-Heterocyclic Carbene Catalysis.Angewandte Chemie (International ed. in English) · 2025Article
- Photochemical Insights on Acyl Azolium Salts Enable the Design of a Tandem Hydrogen Atom Transfer/Halogen Atom Transfer Acylation of Alkyl Bromides and Chlorides.Journal of the American Chemical Society · 2025Article
- Intramolecular PCET of α-Keto Acids: Synthesis of Trifluoromethyl Ketones via Ketyl Radicals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Base-Promoted Homolytic Aromatic Substitution (BHAS) Reactions and Hydrodehalogenations Driven by Green Light and an Iron(III)-NHC Photoredox Catalyst.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Catalytic Enantioselective Hydrogen Atom Abstraction Enables the Asymmetric Oxidation ofJournal of the American Chemical Society · 2024Article
- Catalytic Aldehyde-Alkyne Couplings Triggered by Ketyl Radicals.Organic letters · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ketyl radicals are valuable reactive intermediates for synthesis and are used extensively to construct complex, functionalized products from carbonyl substrates. Single electron transfer (SET) reduction of the C[double bond, length as m-dash]O bond of aldehydes and ketones is the classical approach for the formation of ketyl radicals and metal reductants are the archetypal reagents employed. The past decade has, however, witnessed significant advances in the generation and harnessing of ketyl radicals. This tutorial review highlights recent, exciting developments in the chemistry of ketyl radicals by comparing the varied contemporary - for example, using photoredox catalysts - and more classical approaches for the generation and use of ketyl radicals. The review will focus on different strategies for ketyl radical generation, their creative use in new synthetic protocols, strategies for the control of enantioselectivity, and detailed mechanisms where appropriate.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.