Evidence map›Paper›PMID 33972943›Full record

ArticlebioRxiv : the preprint server for biology2021

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19.

Sokratis A Apostolidis, Amrita Sarkar, Heather M Giannini, Rishi R Goel, Divij Mathew, Aae Suzuki, Amy E Baxter, Allison R Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem and 26 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 4 institutions in 1 country.

Sokratis A ApostolidisInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Amrita Sarkar *Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Heather M Giannini *Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rishi R Goel *Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Divij Mathew *Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Aae SuzukiDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Amy E BaxterInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Allison R GreenplateInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Cécile AlanioInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mohamed Abdel-HakeemInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Derek A OldridgeInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Josephine GilesInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jennifer E WuInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Zeyu ChenInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Yinghui Jane HuangInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Ajinkya PattekarInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sasikanth ManneInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Oliva KuthuruInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jeanette DoughertyInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Brittany WeiderholdDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Ariel R WeismanDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Caroline A G IttnerDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sigrid GoumaDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Debora DunbarDivision of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ian FrankDivision of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Alexander C HuangInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Laura A VellaInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
UPenn COVID Processing Unit
John P ReillyDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Scott E HensleyInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lubica RauovaDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Liang ZhaoDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Nuala J MeyerDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mortimer PonczDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Charles S AbramsDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
E John WherryInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USTranslational Therapeutics (United States) · USParker Institute for Cancer Immunotherapy · US

Funding

Subcellular Mechanisms pf Platelet ActivationP01HL040387 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, JOEL S. · 1988 to 2018
$35.5M
IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1M
Thrombosis Models CoreP01HL120846 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ABRAMS, CHARLES S. · 2014 to 2018
$12.2M
TRAINING IN PULMONARY IMMUNOLOGYT32HL007586 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 1985 to 2025
$8.8M
New Mechanistic Insights & Therapeutic Applications of Megakaryocytes/PlateletsR35HL150698 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Mortimer Poncz · 2020 to 2026
$7.3M
Training Program/Rheumatic DiseasesT32AR076951 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI EDWARD M BEHRENS, Peter A Merkel · 2020 to 2026
$2.6M
Targeting Angiopoietin-2 in ARDSR01HL137006 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2017 to 2021
$2.5M
Reconsidering the IL-1 axis in sepsis-associated ARDSR01HL137915 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2017 to 2020
$2.1M
Cellular and transcriptional control of exhausted CD8 T cells lineage dynamicsR01AI105343 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2014 to 2017
$1.6M
The Penn-StARR Program for Research in ResidencyR38HL143613 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KLEIN, PETER S · 2018 to 2021
$1.4M
Role of tumor burden in limiting durable reinvigoration by PD-1 blockadeK08CA230157 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HUANG, ALEXANDER · 2019 to 2023
$1.0M
Transcriptional and epigenetic regulation of Tfh dysfunction in HIVK08AI136660 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI VELLA, LAURA A · 2018 to 2022
$778k
NCI NIH HHS F99 CA234842NCI NIH HHS K00 CA234842NCI NIH HHS K08 CA230157NCI NIH HHS T32 CA009140NHLBI NIH HHS P01 HL040387NHLBI NIH HHS P01 HL120846NHLBI NIH HHS R01 HL137006NHLBI NIH HHS R01 HL137915NHLBI NIH HHS R35 HL150698NHLBI NIH HHS R38 HL143613NHLBI NIH HHS T32 HL007586NIAID NIH HHS K08 AI136660NIAID NIH HHS R01 AI105343NIAMS NIH HHS T32 AR076951
6 · The paper itself

Abstract

Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflammation and pre-existing cardiovascular disease. Platelets are important mediators and sensors of inflammation and are directly affected by cardiovascular stressors. In this report, we found that platelets from severely ill, hospitalized COVID-19 patients exhibit higher basal levels of activation measured by P-selectin surface expression, and have a poor functional reserve upon COVER ILLUSTRATION: ONE-SENTENCE SUMMARY: The FcγRIIA and C5a-C5aR pathways mediate platelet hyperactivation in COVID-19.

Identifiers

PMID33972943
PMCPMC8109205
OpenAlexW3157511280

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.