Evidence map›Paper›PMID 33972941›Full record

ArticlebioRxiv : the preprint server for biology2021

The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M

Ali Ebrahim, Blake T Riley, Desigan Kumaran, Babak Andi, Martin R Fuchs, Sean McSweeney, Daniel A Keedy

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ali EbrahimDiamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.ORCID 0000-0003-2661-381X
Blake T RileyStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0003-2176-0503
Desigan KumaranBiology Department, Brookhaven National Laboratory, Upton, NY 11973.
Babak AndiNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973.ORCID 0000-0002-7666-639X
Martin R FuchsNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973.ORCID 0000-0001-9784-0927
Sean McSweeneyNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973.ORCID 0000-0002-3758-3161
Daniel A KeedyStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0002-9184-7586

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
Nanuq Cryocooling SystemR35GM133769 · NIGMS · ADVANCED SCIENCE RESEARCH CENTER · PI Daniel A Keedy · 2019 to 2026
$2.9M
NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R35 GM133769
6 · The paper itself

Abstract

The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague the globe. The SARS-CoV-2 main protease, or M

Indexed as

allosteryprotein flexibilityprotein structuresolventX-ray crystallography

Identifiers

PMID33972941
PMCPMC8109201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.