Evidence map›Paper›PMID 33972939›Full record

ArticlebioRxiv : the preprint server for biology2021

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.

Antonio Muruato, Michelle N Vu, Bryan A Johnson, Meredith E Davis-Gardner, Abigail Vanderheiden, Kumari Lokugmage, Craig Schindewolf, Patricia A Crocquet-Valdes, Rose M Langsjoen, Jessica A Plante and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Antonio MuruatoDepartments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Michelle N VuMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Bryan A JohnsonMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Meredith E Davis-GardnerDepartment of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Abigail VanderheidenDepartment of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Kumari LokugmageMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Craig SchindewolfMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Patricia A Crocquet-ValdesPathology, University of Texas Medical Branch, Galveston, TX, USA.
Rose M LangsjoenDepartments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Jessica A PlanteMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Kenneth S PlanteMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Scott C WeaverMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Kari DebbinkDepartment of Natural Science, Bowie State University, Bowie, MD, USA.
Andrew L RouthDepartments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
David WalkerPathology, University of Texas Medical Branch, Galveston, TX, USA.
Mehul S SutharDepartment of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Xuping XieDepartments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Pei-Yong ShiDepartments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Xuping XieDepartments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Vineet D MenacheryMicrobiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Systems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0M
World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
UTMB Clinical and Translational Science AwardTL1TR001440 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HOMMEL, JONATHAN DEAN · 2015 to 2024
$3.4M
Identifying host and viral correlates for coronavirus pathogenesisR01AI153602 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI JOHNSON, BRYAN A · 2020 to 2023
$2.0M
Innate immune mechanisms of virologic control and recovery from flavivirus encephalitisR56AI147623 · NIAID · WASHINGTON UNIVERSITY · PI KLEIN, ROBYN S., SUTHAR, MEHUL SHAMAL · 2020 to 2020
$775k
The Host Genetics of Age-Dependent SusceptibilityR21AI145400 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MENACHERY, VINEET D · 2020 to 2021
$451k
NCATS NIH HHS TL1 TR001440NIAID NIH HHS R01 AI153602NIAID NIH HHS R21 AI145400NIAID NIH HHS R24 AI120942NIAID NIH HHS R56 AI147623NIAID NIH HHS U19 AI090023NIH HHS P51 OD011132
6 · The paper itself

Abstract

The emergence of SARS-CoV-2 has resulted in a worldwide pandemic causing significant damage to public health and the economy. Efforts to understand the mechanisms of COVID-19 disease have been hampered by the lack of robust mouse models. To overcome this barrier, we utilized a reverse genetic system to generate a mouse-adapted strain of SARS-CoV-2. Incorporating key mutations found in SARSCoV-2 variants, this model recapitulates critical elements of human infection including viral replication in the lung, immune cell infiltration, and significant

Identifiers

PMID33972939
PMCPMC8109199

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.