Evidence map›Paper›PMID 33972800›Full record

ArticleNature neuroscience2021

Wireless multilateral devices for optogenetic studies of individual and social behaviors.

Yiyuan Yang, Mingzheng Wu, Abraham Vázquez-Guardado, Amy J Wegener, Jose G Grajales-Reyes, Yujun Deng, Taoyi Wang, Raudel Avila, Justin A Moreno, Samuel Minkowicz and 23 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 203 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
  7. Article
  8. Article
  9. Photonic Nanomaterials for Wearable Health Solutions.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 10 institutions in 5 countries.

Yiyuan Yang *Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0003-1262-354X
Mingzheng Wu *Department of Neurobiology, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0003-4415-6296
Abraham Vázquez-Guardado *Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-0648-5921
Amy J WegenerUS Army Research Laboratory, Aberdeen Proving Ground, MD, USA.ORCID http://orcid.org/0000-0003-4674-1181
Jose G Grajales-ReyesWashington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-3861-6842
Yujun DengDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
Taoyi WangDepartment of Physics, Tsinghua University, Beijing, China.
Raudel AvilaDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
Justin A MorenoUS Army Research Laboratory, Aberdeen Proving Ground, MD, USA.
Samuel MinkowiczDepartment of Neurobiology, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0003-1555-1158
Vasin DumrongprechachanDepartment of Neurobiology, Northwestern University, Evanston, IL, USA.
Jungyup LeeNeurolux Inc, Evanston, IL, USA.
Shuangyang ZhangDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
Alex A LegariaWashington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO, USA.
Yuhang MaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China.
Sunita MehtaCSIR-Central Scientific Instruments Organization, Ministry of Science & Technology, Sector 30-C, Chandigarh, India.
Daniel FranklinCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.
Layne HartmanDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Wubin BaiCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0003-2872-5559
Mengdi HanCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.
Hangbo ZhaoCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-5229-4192
Wei LuCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.
Yongjoon YuChemistry of Life Processes Institutes, Northwestern University, Evanston, IL, USA.
Xing ShengDepartment of Electronic Engineering, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-8744-1700
Anthony BanksCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.
Xinge YuDepartment of Biomedical Engineering, City University of Hong Kong, Kowloong Tong, Hong Kong.ORCID http://orcid.org/0000-0003-0522-1171
Zoe R DonaldsonPsychology and Neuroscience, Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0001-6699-7905
Robert W GereauWashington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-5428-4251
Cameron H GoodCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.
Zhaoqian XieState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, P.R. China. zxie@dlut.edu.cn.ORCID http://orcid.org/0000-0003-1320-817X
Yonggang HuangDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, USA. y-huang@northwestern.edu.ORCID http://orcid.org/0000-0002-0483-8359
Yevgenia KozorovitskiyDepartment of Neurobiology, Northwestern University, Evanston, IL, USA. yevgenia.kozorovitskiy@northwestern.edu.ORCID http://orcid.org/0000-0002-3710-1484
John A RogersDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.ORCID http://orcid.org/0000-0002-2980-3961
Northwestern University · USWashington University in St. Louis · USDEVCOM Army Research Laboratory · USTsinghua University · CNCentral Scientific Instruments Organisation · INCity University of Hong Kong · HKDalian University of Technology · CNLux Research (United States) · USTianjin University · CNUniversity of Colorado Boulder · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Mechanisms of Central SensitizationR01NS106953 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2018 to 2022
$2.7M
Neuronal basis of social motivation and the failure to adapt to lossDP2MH119427 · NIMH · UNIVERSITY OF COLORADO · PI DONALDSON, ZOE REBECCA · 2018 to 2019
$2.5M
Neurohypophyseal regulation of midbrain dopamine systems.R01MH117111 · NIMH · NORTHWESTERN UNIVERSITY · PI KOZOROVITSKIY, YEVGENIA · 2018 to 2022
$2.0M
Mechanisms of striatal structural and functional plasticity.R01NS107539 · NINDS · NORTHWESTERN UNIVERSITY · PI KOZOROVITSKIY, YEVGENIA · 2018 to 2022
$1.7M
GENETIC DISSECTION OF BRAINSTEM CIRCUITS AND THEIR ROLE IN PERSISTENT INFLAMMATORY PAINF31NS103472 · NINDS · WASHINGTON UNIVERSITY · PI GRAJALES REYES, JOSE G · 2017 to 2019
$61k
NCI NIH HHS P30 CA060553NIA NIH HHS T32 AG020506NIGMS NIH HHS T32 GM007200NIMH NIH HHS DP2 MH119427NIMH NIH HHS R01 MH117111NINDS NIH HHS F31 NS103472NINDS NIH HHS R01 NS106953NINDS NIH HHS R01 NS107539
6 · The paper itself

Abstract

Advanced technologies for controlled delivery of light to targeted locations in biological tissues are essential to neuroscience research that applies optogenetics in animal models. Fully implantable, miniaturized devices with wireless control and power-harvesting strategies offer an appealing set of attributes in this context, particularly for studies that are incompatible with conventional fiber-optic approaches or battery-powered head stages. Limited programmable control and narrow options in illumination profiles constrain the use of existing devices. The results reported here overcome these drawbacks via two platforms, both with real-time user programmability over multiple independent light sources, in head-mounted and back-mounted designs. Engineering studies of the optoelectronic and thermal properties of these systems define their capabilities and key design considerations. Neuroscience applications demonstrate that induction of interbrain neuronal synchrony in the medial prefrontal cortex shapes social interaction within groups of mice, highlighting the power of real-time subject-specific programmability of the wireless optogenetic platforms introduced here.

Indexed as

Social BehaviorAnimalsMiceOptogeneticsWireless Technology

Identifiers

PMID33972800
PMCPMC8694284
OpenAlexW3161909955

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.