Evidence map›Paper›PMID 33972627›Full record

ArticleScientific reports2021

10-hydroxy-2E-decenoic acid (10HDA) does not promote caste differentiation in Melipona scutellaris stingless bees.

Luiza Diniz Ferreira Borges, Letícia Leandro Batista, Serena Mares Malta, Tamiris Sabrina Rodrigues, Jéssica Regina da Costa Silva, Gabriela Venturini, Alexandre da Costa Pereira, Pedro Henrique Gonçalves Guedes, Carlos Ueira-Vieira, Ana Maria Bonetti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Luiza Diniz Ferreira BorgesInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil. luizadfb@hotmail.com.
Letícia Leandro BatistaInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil.
Serena Mares MaltaInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil.
Tamiris Sabrina RodriguesInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil.
Jéssica Regina da Costa SilvaInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil.
Gabriela VenturiniDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Alexandre da Costa PereiraDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Pedro Henrique Gonçalves GuedesInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil.
Carlos Ueira-VieiraInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil.
Ana Maria BonettiInstitute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E building, Uberlândia, MG, 38405-319, Brazil. anabonetti@ufu.br.
Universidade Federal de Uberlândia · BRHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In bees from genus Melipona, differential feeding is not enough to fully explain female polyphenism. In these bees, there is a hypothesis that in addition to the environmental component (food), a genetic component is also involved in caste differentiation. This mechanism has not yet been fully elucidated and may involve epigenetic and metabolic regulation. Here, we verified that the genes encoding histone deacetylases HDAC1 and HDAC4 and histone acetyltransferase KAT2A were expressed at all stages of Melipona scutellaris, with fluctuations between developmental stages and castes. In larvae, the HDAC genes showed the same profile of Juvenile Hormone titers-previous reported-whereas the HAT gene exhibited the opposite profile. We also investigated the larvae and larval food metabolomes, but we did not identify the putative queen-fate inducing compounds, geraniol and 10-hydroxy-2E-decenoic acid (10HDA). Finally, we demonstrated that the histone deacetylase inhibitor 10HDA-the major lipid component of royal jelly and hence a putative regulator of honeybee caste differentiation-was unable to promote differentiation in queens in Melipona scutellaris. Our results suggest that epigenetic and hormonal regulations may act synergistically to drive caste differentiation in Melipona and that 10HDA is not a caste-differentiation factor in Melipona scutellaris.

Indexed as

Gene Expression Regulation, DevelopmentalHierarchy, SocialAcyclic MonoterpenesAnimalsBeesEpigenesis, GeneticFatty AcidsFatty Acids, MonounsaturatedFeeding BehaviorFemaleHistone AcetyltransferasesHistone DeacetylasesInsect ProteinsJuvenile HormonesRoyal Jelly10-hydroxy-2-decenoic acidAcyclic MonoterpenesFatty AcidsFatty Acids, MonounsaturatedgeraniolHistone AcetyltransferasesHistone DeacetylasesInsect ProteinsJuvenile HormonesRoyal Jelly

Identifiers

PMID33972627
PMCPMC8110752
OpenAlexW3161112763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.