ArticleNature communications2021
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
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In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
What it found
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- TIR domain proteins: regulatory mechanisms in the tumor immune microenvironment, clinical translation strategies, and prospects for precision therapy applications.Frontiers in immunology · 2025Pooled it
- Review
- MyD88 self-assembles into supramolecular filaments to amplify NF-κB signaling.Fundamental research · 2026Article
- Structural Mechanism of Receptor-Triggered MyD88 Oligomeric Assembly in Innate Immune Signaling.Nature communications · 2026Article
- Single-cell structural biology with intracellular electron crystallography.Nature communications · 2026Article
- Direct from the seed: an atomic resolution protein structure by ab initio MicroED.Nature communications · 2026Article
- Article
- Molecular characterisation of the Bacillus subtilis SpbK antiphage defence system.Nature communications · 2025Article
- Decoding necrosome assembly: harmonizing signal amplification and attenuation through optimal RIP3 stoichiometry.Nature communications · 2025Article
- Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer.Nature communications · 2025Article
- The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanism behindGut microbes · 2025Article
- Standards for MicroED.Acta crystallographica. Section C, Structural chemistry · 2025Article
- Comprehensive microcrystal electron diffraction sample preparation for cryo-EM.Nature protocols · 2025Review
- Structure-guided insights into TIR-mediated bacterial and eukaryotic immunity.Structure (London, England : 1993) · 2025Review
- Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levels.The Biochemical journal · 2025Review
- Unraveling atomic complexity from frozen samples.Structural dynamics (Melville, N.Y.) · 2025Article
- Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- In silico analysis of Triphala-derived polyphenols as inhibitors of TIR-TIR homodimerization in the inflammatory pathway.Frontiers in bioinformatics · 2025Article
- Structural and dynamic properties of IL1 receptors.Frontiers in immunology · 2025Review
- o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.Journal of enzyme inhibition and medicinal chemistry · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 9 institutions in 4 countries.
Max T B Clabbers *Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5466-6508
Susannah Holmes *Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Timothy W MuusseSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4384-5647
Parimala R VajjhalaSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Sara J ThygesenSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Alpeshkumar K MaldeInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.ORCID http://orcid.org/0000-0002-8181-1619
Dominic J B HunterSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Tristan I CrollCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Leonie FlueckigerAustralian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Jeffrey D NansonSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-1306-1948
Md Habibur RahamanSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Andrew AquilaLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA.ORCID http://orcid.org/0000-0003-0358-2774
Mark S HunterLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA.ORCID http://orcid.org/0000-0002-0110-7075
Mengning LiangLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA.
Chun Hong YoonLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA.
Jingjing ZhaoDepartment of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8444-6883
Nadia A ZatsepinAustralian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-1757-0205
Brian AbbeyAustralian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-6504-0503
Emma SiereckiEMBL Australia Node in Single Molecule Science, University of New South Wales, Kensington, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9970-868X
Yann GambinEMBL Australia Node in Single Molecule Science, University of New South Wales, Kensington, New South Wales, Australia.
Katryn J StaceySchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Connie DarmaninAustralian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia. c.darmanin@latrobe.edu.au.ORCID http://orcid.org/0000-0002-4449-2233
Bostjan KobeSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia. b.kobe@uq.edu.au.ORCID http://orcid.org/0000-0001-9413-9166
Hongyi XuDepartment of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden. hongyi.xu@mmk.su.se.ORCID http://orcid.org/0000-0002-8271-3906
Thomas VeInstitute for Glycomics, Griffith University, Southport, Queensland, Australia. t.ve@griffith.edu.au.ORCID http://orcid.org/0000-0002-0113-1905
The University of Queensland · AUAustralian Research Council · AUSLAC National Accelerator Laboratory · USGriffith University · AUStockholm University · SEUNSW Sydney · AUQueensland University of Technology · AUUniversity of California, Los Angeles · USUniversity of Cambridge · GB
Funding
Wellcome TrustWellcome Trust 209407/Z/17/Z
Abstract
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MAL
Indexed as
CrystallographyDimerizationHEK293 CellsHumansMembrane GlycoproteinsModels, MolecularMolecular Dynamics SimulationMutationMyeloid Differentiation Factor 88Protein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein DomainsReceptors, Interleukin-1Recombinant ProteinsSignal TransductionToll-Like Receptor 4Membrane GlycoproteinsMYD88 protein, humanMyeloid Differentiation Factor 88Receptors, Interleukin-1Recombinant ProteinsTIRAP protein, humanTLR4 protein, humanToll-Like Receptor 4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.