ArticleNature communications2021
Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 133 citations in OpenAlex.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The representational geometry of emotional states in basolateral amygdala.Nature neuroscience · 2026Article
- An olfactory-prefrontal cortical circuit supports social recognition.Research square · 2026Article
- Human forebrain neural synchronization and entrainment to breathing during wakefulness, sleep, and external mechanical ventilation.Nature communications · 2026Article
- Respiratory pauses highlight sleep architecture in mice.Nature communications · 2026Article
- The Timing of Attentional Distraction Matters in Facilitating Extinction of Trace Fear Memory.Experimental neurobiology · 2026Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.Communications biology · 2026Article
- Vigilance state dissociation induced by 5-MeO-DMT in mice.Communications biology · 2026Article
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- How do we think and what is the neural circuit mechanism for it? Possible roles of working memory and inner speech in thinking.Frontiers in human neuroscience · 2026Article
- AAV9-mediated transduction of memory circuits following convection-enhanced delivery into the olfactory bulbs.Gene therapy · 2025Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Cardiac, respiratory, and gastric rhythms independently modulate motor corticospinal excitability in humans.PLoS biology · 2025Article
- Pleasant odors specifically promote a soothing autonomic response and brain-body coupling through respiratory modulation.Scientific reports · 2025Article
- Dynamic brain-heart interaction in sleep characterized by variational phase-amplitude coupling framework.Communications biology · 2025Article
- Global coordination of brain activity by the breathing cycle.Nature reviews. Neuroscience · 2025Review
- The respiratory cycle modulates distinct dynamics of affective and perceptual decision-making.PLoS computational biology · 2025Article
- Breathing Modulates Network Activity in Frontal Brain Regions during Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain-body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm to the dorsomedial prefrontal cortex (dmPFC) where it organizes neural activity. Reduction of the respiratory-related 4 Hz oscillation, via bulbectomy or optogenetic perturbation of the OB, reduces freezing. Behavioural modelling shows that this is due to a specific reduction in freezing maintenance without impacting its initiation, thus dissociating these two phenomena. dmPFC LFP and firing patterns support the region's specific function in freezing maintenance. In particular, population analysis reveals that network activity tracks 4 Hz power dynamics during freezing and reaches a stable state at 4 Hz peak that lasts until freezing termination. These results provide a potential mechanism and a functional role for bodily feedback in emotions and therefore shed light on the historical James-Cannon debate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.