ArticleNature communications2021
3D mechanical characterization of single cells and small organisms using acoustic manipulation and force microscopy.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Impairment of neuronal activity occurs at the early stages of the aggregation cascade of Aβ1-42 and mutant Tau.Disease models & mechanisms · 2026Article
- Acoustic Bubble Sensing Techniques and Bioapplications.Biosensors · 2026Review
- Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Harnessing Microfluidics for the Effective and Precise Synthesis of Advanced Materials.Micromachines · 2025Review
- The 15th Anniversary ofMaterials (Basel, Switzerland) · 2025Article
- Acousto-optogenetics bandpass stabilizer: A programmable platform for mapping single-cell phenotypic life trajectories.Materials today. Bio · 2025Article
- μSonic-hand: Biomedical micromanipulation driven by acoustic gas-liquid-solid interactions.Science advances · 2025Article
- Label-free spatiotemporal decoding of single-cell fate via acoustic driven 3D tomography.Materials today. Bio · 2024Article
- Ultrasound-induced reorientation for multi-angle optical coherence tomography.Nature communications · 2024Article
- Bidirectional and Stepwise Rotation of Cells and Particles Using Induced Charge Electroosmosis Vortexes.Biosensors · 2024Article
- A vibrating capillary for ultrasound rotation manipulation of zebrafish larvae.Lab on a chip · 2024Article
- High-Resolution Imaging and Morphological Phenotyping ofResearch (Washington, D.C.) · 2024Article
- Acoustic microbubble propulsion, train-like assembly and cargo transport.Nature communications · 2023Article
- In situ sensing physiological properties of biological tissues using wireless miniature soft robots.Science advances · 2023Article
- Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves.Ultrasonics sonochemistry · 2023Review
- 3D AFM Nanomechanical Characterization of Biological Materials.Nanomaterials (Basel, Switzerland) · 2023Article
- Determining Spatial Variability of Elastic Properties for Biological Samples Using AFM.Micromachines · 2023Review
- Massive and efficient encapsulation of single cells in monodisperse droplets and collagen-alginate microgels using a microfluidic device.Frontiers in bioengineering and biotechnology · 2023Article
- Cultivation and Imaging ofBioengineering (Basel, Switzerland) · 2022Article
- A robot-assisted acoustofluidic end effector.Nature communications · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative micromechanical characterization of single cells and multicellular tissues or organisms is of fundamental importance to the study of cellular growth, morphogenesis, and cell-cell interactions. However, due to limited manipulation capabilities at the microscale, systems used for mechanical characterizations struggle to provide complete three-dimensional coverage of individual specimens. Here, we combine an acoustically driven manipulation device with a micro-force sensor to freely rotate biological samples and quantify mechanical properties at multiple regions of interest within a specimen. The versatility of this tool is demonstrated through the analysis of single Lilium longiflorum pollen grains, in combination with numerical simulations, and individual Caenorhabditis elegans nematodes. It reveals local variations in apparent stiffness for single specimens, providing previously inaccessible information and datasets on mechanical properties that serve as the basis for biophysical modelling and allow deeper insights into the biomechanics of these living systems.
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Registered trials
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