Trial reportNature communications2021
Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke.
Trial report in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A reporting guideline for randomized trials and observational studies using mediation analysis: AGReMA.Nature medicine · 2022Guideline
- Early effect of thrombolysis on structural brain network organisation after anterior-circulation stroke in the randomized WAKE-UP trial.Human brain mapping · 2022Trial
- Beyond proportional recovery in wake-up stroke: unsupervised recovery clusters based on the NIHSS.Journal of neuroengineering and rehabilitation · 2026Article
- The structural reserve of brain networks influences outcomes after a stroke.Brain communications · 2026Article
- A Metalloporphyrin Nanosystem Enables Non-Invasive Visualization and Specific Treatment for Thrombosis and Ischemic Stroke.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Localized network damage related to white matter hyperintensities is linked to worse outcome after severe stroke.Neurological research and practice · 2025Article
- Frontoparietal Structural Network Disconnections Correlate With Outcome After a Severe Stroke.Human brain mapping · 2024Article
- Revascularization Therapies for Ischemic Stroke and Association With Risk of Epilepsy: A Danish Nationwide Register-Based Study.Journal of the American Heart Association · 2024Article
- Data-Driven Analysis Reveals Cortical Infarction Patterns Correlated With Inflammation and Prognosis: A Retrospective, Multicenter Cohort Study.Journal of the American Heart Association · 2024Article
- Disruptions in Structural and Functional Connectivity Relate to Poststroke Fatigue.Brain connectivity · 2023Article
- The role of neurophysiological tools in the evaluation of ischemic stroke evolution: a narrative review.Frontiers in neurology · 2023Review
- Structural disconnection-based prediction of poststroke depression.Translational psychiatry · 2022Article
- Effect of Alteplase Thrombolysis on Coagulation Function and Nerve Function of Patients with Ischemic Stroke.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- White matter degeneration revealed by fiber-specific analysis relates to recovery of hand function after stroke.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
20 authors at 10 institutions in 7 countries.
Funding
Abstract
Thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke aims to restore compromised blood flow and prevent further neuronal damage. Despite the proven clinical efficacy of this treatment, little is known about the short-term effects of systemic thrombolysis on structural brain connectivity. In this secondary analysis of the WAKE-UP trial, we used MRI-derived measures of infarct size and estimated structural network disruption to establish that thrombolysis is associated not only with less infarct growth, but also with reduced loss of large-scale connectivity between grey-matter areas after stroke. In a causal mediation analysis, infarct growth mediated a non-significant 8.3% (CI
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.