Evidence map›Paper›PMID 33972466›Full record

ArticleExperimental neurobiology2021

Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling.

Hye Young Shin, Kyung-Seok Han, Hyung Woo Park, Yun Hwa Hong, Yona Kim, Hyo Eun Moon, Kwang Woo Park, Hye Ran Park, C Justin Lee, Kiyoung Lee and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Hye Young ShinDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Kyung-Seok HanCenter for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Korea.
Hyung Woo ParkDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Yun Hwa HongDepartment of Neurophysiology, Seoul National University College of Medicine, Seoul 03082, Korea.
Yona KimDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Hyo Eun MoonDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Kwang Woo ParkDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Hye Ran ParkDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
C Justin LeeCenter for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Korea.
Kiyoung LeeDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Sang Jeong KimDepartment of Neurophysiology, Seoul National University College of Medicine, Seoul 03082, Korea.
Man Seung HeoSmart Healthcare Medical Device Research Center, Samsung Medical Center, Seoul 06351, Korea.
Sung-Hye ParkDepartment of Pathology, Seoul National University College of Medicine, Seoul 03082, Korea.
Dong Gyu KimDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Sun Ha PaekDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul 03082, Korea.
Seoul National University · KRInstitute for Basic Science · KRSamsung Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central neurocytoma (CN) has been known as a benign neuronal tumor. In rare cases, CN undergoes malignant transformation to glioblastomas (GBM). Here we examined its cellular origin by characterizing differentiation potential and gene expression of CN-spheroids. First, we demonstrate that both CN tissue and cultured primary cells recapitulate the hierarchal cellular composition of subventricular zone (SVZ), which is comprised of neural stem cells (NSCs), transit amplifying progenitors (TAPs), and neuroblasts. We then derived spheroids from CN which displayed EGFR+/ MASH+ TAP and BLBP+ radial glial cell (RGC) characteristic, and mitotic neurogenesis and gliogenesis by single spheroids were observed with cycling multipotential cells. CN-spheroids expressed increased levels of pluripotency and tumor stem cell genes such as

Indexed as

Central neurocytomaGene Set Enrichment AnalysisNeural stem cellRadial glia cellsSubventricular zoneTransit-amplifying cellsTumor spheroids

Identifiers

PMID33972466
PMCPMC8118755
OpenAlexW3161551219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.