Evidence map›Paper›PMID 33972443›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.

Jean Ching-Yi Tien, Seema Chugh, Andrew E Goodrum, Yunhui Cheng, Rahul Mannan, Yuping Zhang, Lisha Wang, Vijaya L Dommeti, Xiaoming Wang, Alice Xu and 7 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Non-small cell lung cancer organoids: Advances and challenges in current applications.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  6. Effects of multi-walled carbon nanotubes on message and Micro-RNA in human lung BEAS-2B cells.Materials express : an international journal on multidisciplinary materials research · 2024
    Article
  7. Article
  8. Progress and application of lung-on-a-chip for lung cancer.Frontiers in bioengineering and biotechnology · 2024
    Review
  9. Review
  10. CBX4 deletion promotes tumorigenesis under KrasSignal transduction and targeted therapy · 2023
    Article
  11. Article
  12. Article
  13. DNA and RNA Binding Proteins: From Motifs to Roles in Cancer.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. Interplay between K-RAS and miRNAs.Trends in cancer · 2022
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Jean Ching-Yi TienMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Seema ChughMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Andrew E GoodrumMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Yunhui ChengMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Rahul MannanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-6642-0468
Yuping ZhangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Lisha WangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Vijaya L DommetiMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Xiaoming WangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-9697-5571
Alice XuMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Jennifer HonMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Carson KenumMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Fengyun SuMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Rui WangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-5356-9685
Xuhong CaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Sunita ShankarMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8743-7480
Arul M ChinnaiyanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109; arul@umich.edu.
University of Michigan · USHoward Hughes Medical Institute · US

Funding

Tissue/InformaticsP50CA186786 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu · 2014 to 2026
$27.6M
Exploring Precision Oncology: From Gene Fusions to lncRNAsR35CA231996 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M · 2018 to 2024
$6.4M
Discovery and qualification of transcriptomic biomarkers for the early detection of aggressive prostate cancerU01CA214170 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M · 2016 to 2021
$3.3M
NCI NIH HHS P50 CA186786NCI NIH HHS R35 CA231996NCI NIH HHS U01 CA214170
6 · The paper itself

Abstract

Lung cancer is the deadliest malignancy in the United States. Non-small cell lung cancer (NSCLC) accounts for 85% of cases and is frequently driven by activating mutations in the gene encoding the KRAS GTPase (e.g.,

Indexed as

AnimalsArgonaute ProteinsCarcinoma, Non-Small-Cell LungDisease Models, AnimalDisease ProgressionLung NeoplasmsMAP Kinase Signaling SystemMiceMice, Inbred C57BLProto-Oncogene Proteins p21(ras)Signal TransductionAgo2 protein, mouseArgonaute ProteinsHras protein, mouseProto-Oncogene Proteins p21(ras)AGO2KRASnonsmall cell lung cancer

Identifiers

PMID33972443
PMCPMC8157917
OpenAlexW3162626666

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.