Evidence map›Paper›PMID 33972428›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Presynaptic coupling by electrical synapses coordinates a rhythmic behavior by synchronizing the activities of a neuron pair.

Ukjin Choi, Han Wang, Mingxi Hu, Sungjin Kim, Derek Sieburth

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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  10. A leak KPNAS nexus · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ukjin ChoiDevelopment, Stem Cell, and Regenerative Medicine Graduate Program, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-4295-9581
Han WangZilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-1933-5762
Mingxi HuZilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-3813-9222
Sungjin KimZilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033.
Derek SieburthZilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033; sieburth@usc.edu.ORCID 0000-0002-1224-2758
University of Southern California · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Stress Regulation of Synaptic TransmissionR01NS099414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DEREK SIEBURTH · 2017 to 2026
$3.1M
Sphingolipid signaling in mitochondrial surveillanceR01NS110730 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SIEBURTH, DEREK · 2019 to 2023
$1.8M
NIH HHS P40 OD010440NINDS NIH HHS R01 NS099414NINDS NIH HHS R01 NS110730
6 · The paper itself

Abstract

Electrical synapses are specialized structures that mediate the flow of electrical currents between neurons and have well known roles in synchronizing the activities of neuronal populations, both by mediating the current transfer from more active to less active neurons and by shunting currents from active neurons to their less active neighbors. However, how these positive and negative functions of electrical synapses are coordinated to shape rhythmic synaptic outputs and behavior is not well understood. Here, using a combination of genetics, behavioral analysis, and live calcium imaging in

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCalciumCalcium ChannelsConnexinsElectrical SynapsesGap JunctionsGene Expression RegulationGenes, ReporterGreen Fluorescent ProteinsLuminescent ProteinsMolecular ImagingMotor NeuronsMuscle ProteinsPeriodicityCaenorhabditis elegans ProteinsCalciumCalcium ChannelsConnexinsEgl-19 protein, C elegansGreen Fluorescent ProteinsLuminescent ProteinsMuscle ProteinsRed Fluorescent ProteinC. eleganselectrical synapseinnexinlateral excitationshunting inhibition

Identifiers

PMID33972428
PMCPMC8157971
OpenAlexW3161339362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.