Evidence map›Paper›PMID 33972425›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.

Teije C Middelkoop, Júlia Garcia-Baucells, Porfirio Quintero-Cadena, Lokesh G Pimpale, Shahrzad Yazdi, Paul W Sternberg, Peter Gross, Stephan W Grill

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Contractile forces direct the chiral swirling of minimal cell collectives.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Left-right symmetry breaking: learning from the chicken.Frontiers in cell and developmental biology · 2025
    Review
  8. Article
  9. Dynamics of multicellular swirling on micropatterned substrates.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Chiral growth of adherent filopodia.Biophysical journal · 2023
    Article
  12. Article
  13. Three-dimensional chiral morphodynamics of chemomechanical active shells.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Teije C MiddelkoopMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.ORCID 0000-0002-0346-6143
Júlia Garcia-BaucellsMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.ORCID 0000-0001-7874-7671
Porfirio Quintero-CadenaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-0067-5844
Lokesh G PimpaleMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Shahrzad YazdiDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142.ORCID 0000-0003-1988-4320
Paul W SternbergDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-7699-0173
Peter GrossMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.ORCID 0000-0002-4258-6105
Stephan W GrillMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; grill@mpi-cbg.de.ORCID 0000-0002-2290-5826
Max Planck Institute of Molecular Cell Biology and Genetics · DECalifornia Institute of Technology · USMassachusetts Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proper left-right symmetry breaking is essential for animal development, and in many cases, this process is actomyosin-dependent. In

Indexed as

ActomyosinAnimalsAnimals, Genetically ModifiedBlastomeresBody PatterningCaenorhabditis elegansCaenorhabditis elegans ProteinsCerebral CortexEmbryo, NonmammalianForminsFunctional LateralityrhoA GTP-Binding ProteinSignal TransductionTorqueActomyosinCaenorhabditis elegans Proteinscyk-1 protein, C elegansForminsrhoA GTP-Binding ProteinC. elegansForminleft–right asymmetryRhoA signaling

Identifiers

PMID33972425
PMCPMC8157923
OpenAlexW3161396725

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.